Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study

Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study

Interferon beta (IFN-β) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN-β use, has been recently described. For this reason, we tested the effect of...

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Main Authors: Vincenzo Dattola, Lilla Bonanno, Antonino Naro, Antonino Chillura, Anna Lisa Logiudice, Edoardo Sessa, Fausto Famà, Angelo Quartarone, Rocco Salvatore Calabrò, Silvia Marino, Margherita Russo
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2017/5421416
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spelling doaj-c4e4dfed30c04c049de88853e7ce25cf2020-11-25T00:10:16ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/54214165421416Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot StudyVincenzo Dattola0Lilla Bonanno1Antonino Naro2Antonino Chillura3Anna Lisa Logiudice4Edoardo Sessa5Fausto Famà6Angelo Quartarone7Rocco Salvatore Calabrò8Silvia Marino9Margherita Russo10IRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyDepartment of Human Pathology, University Hospital of Messina, Via Consolare Valeria, Messina, ItalyDepartment of Clinical and Experimental Medicine, University Hospital of Messina, Via Consolare Valeria, Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, ItalyInterferon beta (IFN-β) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN-β use, has been recently described. For this reason, we tested the effect of once a week intramuscular administration of IFN-β-1A on the function of cerebral vessels in a cohort of RRMS patients. Using transcranial Doppler (TCD) ultrasound, we measured the mean blood flow velocity (MFV) in intracranial vessels 10 h after IFN-β administration. Measurements showed a significant increase in MFV compared to the baseline values in some vessels.http://dx.doi.org/10.1155/2017/5421416
collection DOAJ
language English
format Article
sources DOAJ
author Vincenzo Dattola
Lilla Bonanno
Antonino Naro
Antonino Chillura
Anna Lisa Logiudice
Edoardo Sessa
Fausto Famà
Angelo Quartarone
Rocco Salvatore Calabrò
Silvia Marino
Margherita Russo
spellingShingle Vincenzo Dattola
Lilla Bonanno
Antonino Naro
Antonino Chillura
Anna Lisa Logiudice
Edoardo Sessa
Fausto Famà
Angelo Quartarone
Rocco Salvatore Calabrò
Silvia Marino
Margherita Russo
Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
BioMed Research International
author_facet Vincenzo Dattola
Lilla Bonanno
Antonino Naro
Antonino Chillura
Anna Lisa Logiudice
Edoardo Sessa
Fausto Famà
Angelo Quartarone
Rocco Salvatore Calabrò
Silvia Marino
Margherita Russo
author_sort Vincenzo Dattola
title Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
title_short Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
title_full Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
title_fullStr Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
title_full_unstemmed Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
title_sort relationship between interferon beta-1a administration and intracranial vascular tone regulation in patients with relapsing-remitting multiple sclerosis: a pilot study
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2017-01-01
description Interferon beta (IFN-β) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN-β use, has been recently described. For this reason, we tested the effect of once a week intramuscular administration of IFN-β-1A on the function of cerebral vessels in a cohort of RRMS patients. Using transcranial Doppler (TCD) ultrasound, we measured the mean blood flow velocity (MFV) in intracranial vessels 10 h after IFN-β administration. Measurements showed a significant increase in MFV compared to the baseline values in some vessels.
url http://dx.doi.org/10.1155/2017/5421416
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