CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer

• Main Authors: Weiwei Tang, Kai Fu, Handong Sun, Dawei Rong, Hanjin Wang, Hongyong Cao
• Format: Article
• Language: English
• Published: BMC 2018-09-01
• Series: Molecular Cancer
• Subjects: circRNAs; Microarray; Biomarker; Exosomes; Plasma
• Online Access: http://link.springer.com/article/10.1186/s12943-018-0888-8
• ISSN: 1476-4598

Abstract CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.