Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status
Exposure to Pneumocystis jirovecii (P. jirovecii) can lead to a wide variety of presenting features ranging from colonization in immunocompetent patients with lung disease, to invasive infections in immunocompromised hosts. Colonization by this fungus in patients with chronic obstructive pulmonary d...
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doaj-c4e859df18114d00902151016a2ee37a2020-11-25T03:24:20ZengElsevierBrazilian Journal of Infectious Diseases1413-86702019-09-01235352357Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function statusAlejandra Cañas-Arboleda0Catalina Hernández-Flórez1Javier Garzón2Claudia Marcela Parra-Giraldo3Juan Felipe Burbano4José Enrique Cita-Pardo5Hospital Universitario San Ignacio, Departamento de Medicina Interna, Unidad de Neumología, Bogotá, Colombia; Pontificia Universidad Javeriana, Escuela de Medicina, Bogotá, Colombia; Corresponding author at: Postal address: Carrera 7 #40-62, Hospital Universitario San Ignacio, 7mo piso, Departamento de Medicina Interna, Bogotá, Colombia.Pontificia Universidad Javeriana, Escuela de Medicina, Bogotá, Colombia; Hospital Universitario San Ignacio, Departamento de Medicina Interna, Unidad de Medicina Interna, Bogotá, ColombiaPontificia Universidad Javeriana, Escuela de Medicina, Bogotá, Colombia; Hospital Universitario San Ignacio, Departamento de Medicina Interna. Unidad de Enfermedades Infecciosas, Bogotá, ColombiaPontificia Universidad Javeriana, Facultad de Ciencias, Departamento de Microbiología, Unidad de Investigacion en Proteomica y Micosis humanas, Bogotá, ColombiaHospital Universitario San Ignacio, Departamento de Medicina Interna, Unidad de Medicina Interna, Bogotá, ColombiaHospital Universitario San Ignacio, Departamento de Medicina Interna, Unidad de Medicina Interna, Bogotá, ColombiaExposure to Pneumocystis jirovecii (P. jirovecii) can lead to a wide variety of presenting features ranging from colonization in immunocompetent patients with lung disease, to invasive infections in immunocompromised hosts. Colonization by this fungus in patients with chronic obstructive pulmonary disease (COPD) could be associated with higher rates of exacerbations and impaired lung function in these patients.Our objective was to determine whether colonization by P. jirovecii in patients with COPD is associated with increased exacerbations and deterioration of lung function.This was a prospective cohort study on patients with COPD. All participants meeting selection criteria underwent clinical and microbiological assessments and were then classified as colonized vs. non-colonized patients. Chi-squared tests were performed and multivariate logistic models were fitted in order to obtain risk ratios (RR) with 95% confidence intervals (CI).We documented a frequency of colonization by P. jirovecii of 32.3%. Most patients were categorized as having GOLD B and D COPD. The history of significant exacerbations in the last year, health status impairment (COPD Assesment Tool ≥10), airflow limitation (percent of post-bronchodilator FEV1), and BODEx score (≥5) were similar between groups. After a 52-week follow-up period, the rate of adjusted significant exacerbations did not differ between groups. However, a decrease in FEVI was found in both groups. Keywords: Pneumocystis spp., Pneumocystis jirovecii, Chronic obstructive pulmonary disease, Colombiahttp://www.sciencedirect.com/science/article/pii/S141386701930426X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alejandra Cañas-Arboleda Catalina Hernández-Flórez Javier Garzón Claudia Marcela Parra-Giraldo Juan Felipe Burbano José Enrique Cita-Pardo |
spellingShingle |
Alejandra Cañas-Arboleda Catalina Hernández-Flórez Javier Garzón Claudia Marcela Parra-Giraldo Juan Felipe Burbano José Enrique Cita-Pardo Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status Brazilian Journal of Infectious Diseases |
author_facet |
Alejandra Cañas-Arboleda Catalina Hernández-Flórez Javier Garzón Claudia Marcela Parra-Giraldo Juan Felipe Burbano José Enrique Cita-Pardo |
author_sort |
Alejandra Cañas-Arboleda |
title |
Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status |
title_short |
Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status |
title_full |
Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status |
title_fullStr |
Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status |
title_full_unstemmed |
Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status |
title_sort |
colonization by pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2019-09-01 |
description |
Exposure to Pneumocystis jirovecii (P. jirovecii) can lead to a wide variety of presenting features ranging from colonization in immunocompetent patients with lung disease, to invasive infections in immunocompromised hosts. Colonization by this fungus in patients with chronic obstructive pulmonary disease (COPD) could be associated with higher rates of exacerbations and impaired lung function in these patients.Our objective was to determine whether colonization by P. jirovecii in patients with COPD is associated with increased exacerbations and deterioration of lung function.This was a prospective cohort study on patients with COPD. All participants meeting selection criteria underwent clinical and microbiological assessments and were then classified as colonized vs. non-colonized patients. Chi-squared tests were performed and multivariate logistic models were fitted in order to obtain risk ratios (RR) with 95% confidence intervals (CI).We documented a frequency of colonization by P. jirovecii of 32.3%. Most patients were categorized as having GOLD B and D COPD. The history of significant exacerbations in the last year, health status impairment (COPD Assesment Tool ≥10), airflow limitation (percent of post-bronchodilator FEV1), and BODEx score (≥5) were similar between groups. After a 52-week follow-up period, the rate of adjusted significant exacerbations did not differ between groups. However, a decrease in FEVI was found in both groups. Keywords: Pneumocystis spp., Pneumocystis jirovecii, Chronic obstructive pulmonary disease, Colombia |
url |
http://www.sciencedirect.com/science/article/pii/S141386701930426X |
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