Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4
Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient KitW-sh/W-sh mice display significantly increased astrogliosis and T cell infiltration as w...
Main Authors: | Sofie Nelissen, Tim Vangansewinkel, Nathalie Geurts, Lies Geboes, Evi Lemmens, Pia M. Vidal, Stefanie Lemmens, Leen Willems, Francesco Boato, Dearbhaile Dooley, Debora Pehl, Gunnar Pejler, Marcus Maurer, Martin Metz, Sven Hendrix |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-02-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996113002581 |
Similar Items
-
The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with <i>Giardia</i> <i>intestinalis</i>
by: Zhiqiang Li, et al.
Published: (2020-04-01) -
Mast Cells Limit Ear Swelling Independently of the Chymase Mouse Mast Cell Protease 4 in an MC903-Induced Atopic Dermatitis-Like Mouse Model
by: Sofie Svanberg, et al.
Published: (2020-08-01) -
Modulation of Mast Cell Toll-Like Receptor 3 Expression and Cytokines Release by Histamine
by: Guogang Xie, et al.
Published: (2018-05-01) -
Novel Strategies to Target Mast Cells in Disease
by: Aida Paivandy, et al.
Published: (2021-02-01) -
Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
by: Gunnar Pejler
Published: (2020-06-01)