Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4

Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4

Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient KitW-sh/W-sh mice display significantly increased astrogliosis and T cell infiltration as w...

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Bibliographic Details
Main Authors: Sofie Nelissen, Tim Vangansewinkel, Nathalie Geurts, Lies Geboes, Evi Lemmens, Pia M. Vidal, Stefanie Lemmens, Leen Willems, Francesco Boato, Dearbhaile Dooley, Debora Pehl, Gunnar Pejler, Marcus Maurer, Martin Metz, Sven Hendrix
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
mMCP4
Mast cell
Inflammation
Spinal cord injury
MCP-1
TNF-α
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002581

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