A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes

A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes

Patients diagnosed with thrombotic thrombocytopenic purpura (TTP) typically present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia; these two clinical manifestations were often believed to be essential indicators of TTP. However, such indicators are not always present in every ca...

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Main Authors: Kevin Yu, Min Yan
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Clinics and Practice
Subjects:
thrombotic thrombocytopenic purpura
blood smear
schistocytes
Online Access:https://www.mdpi.com/2039-7283/11/2/33
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spelling doaj-c4fe017bc62a4729936324b7d13f85cb2021-04-13T23:00:04ZengMDPI AGClinics and Practice2039-72832021-04-01113322322710.3390/clinpract11020033A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic SchistocytesKevin Yu0Min Yan1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USADepartment of Hematology and Oncology, Alta Bates Summit Medical Center, Summit Campus, Oakland, CA 94609, USAPatients diagnosed with thrombotic thrombocytopenic purpura (TTP) typically present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia; these two clinical manifestations were often believed to be essential indicators of TTP. However, such indicators are not always present in every case. Here, we present a patient affected by TTP but showing no distinctive schistocytes on blood smear review. TTP was diagnosed through a critically low level of a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) activity. Awareness of such an atypical presentation of TTP is essential for timely treatment to prevent serious and even fatal outcomes for patients.https://www.mdpi.com/2039-7283/11/2/33thrombotic thrombocytopenic purpurablood smearschistocytes
collection DOAJ
language English
format Article
sources DOAJ
author Kevin Yu
Min Yan
spellingShingle Kevin Yu
Min Yan
A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes
Clinics and Practice
thrombotic thrombocytopenic purpura
blood smear
schistocytes
author_facet Kevin Yu
Min Yan
author_sort Kevin Yu
title A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes
title_short A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes
title_full A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes
title_fullStr A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes
title_full_unstemmed A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes
title_sort case of thrombotic thrombocytopenic purpura without pathognomonic schistocytes
publisher MDPI AG
series Clinics and Practice
issn 2039-7283
publishDate 2021-04-01
description Patients diagnosed with thrombotic thrombocytopenic purpura (TTP) typically present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia; these two clinical manifestations were often believed to be essential indicators of TTP. However, such indicators are not always present in every case. Here, we present a patient affected by TTP but showing no distinctive schistocytes on blood smear review. TTP was diagnosed through a critically low level of a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) activity. Awareness of such an atypical presentation of TTP is essential for timely treatment to prevent serious and even fatal outcomes for patients.
topic thrombotic thrombocytopenic purpura
blood smear
schistocytes
url https://www.mdpi.com/2039-7283/11/2/33
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