Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy
Abstract Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream s...
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doaj-c50debe344004d12b2a1a7e969a3f94e2021-01-10T12:54:30ZengBMCCell & Bioscience2045-37012021-01-0111111110.1186/s13578-020-00504-1Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapyXiuyun Xuan0Lin Zhang1Chunxia Tian2Ting Wu3Haihua Ye4Juanmei Cao5Fangqi Chen6Yan Liang7Huilan Yang8Changzheng Huang9Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gerontology, Jinan City People’s HospitalDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, General Hospital of Southern Theatre CommandDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling pathway. It has recently been reported that IL-22 also contributes to the pathogenesis of many connective tissue diseases (CTDs). In this review, we will discuss the role of IL-22 in several CTDs, such as system lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, systemic sclerosis and dermatomyositis, suggesting that IL-22 may be a potential therapeutic target in CTDs.https://doi.org/10.1186/s13578-020-00504-1Connective tissue diseasesInterleukin-22CytokineIL-22RSignalling pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiuyun Xuan Lin Zhang Chunxia Tian Ting Wu Haihua Ye Juanmei Cao Fangqi Chen Yan Liang Huilan Yang Changzheng Huang |
spellingShingle |
Xiuyun Xuan Lin Zhang Chunxia Tian Ting Wu Haihua Ye Juanmei Cao Fangqi Chen Yan Liang Huilan Yang Changzheng Huang Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy Cell & Bioscience Connective tissue diseases Interleukin-22 Cytokine IL-22R Signalling pathway |
author_facet |
Xiuyun Xuan Lin Zhang Chunxia Tian Ting Wu Haihua Ye Juanmei Cao Fangqi Chen Yan Liang Huilan Yang Changzheng Huang |
author_sort |
Xiuyun Xuan |
title |
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy |
title_short |
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy |
title_full |
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy |
title_fullStr |
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy |
title_full_unstemmed |
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy |
title_sort |
interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy |
publisher |
BMC |
series |
Cell & Bioscience |
issn |
2045-3701 |
publishDate |
2021-01-01 |
description |
Abstract Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling pathway. It has recently been reported that IL-22 also contributes to the pathogenesis of many connective tissue diseases (CTDs). In this review, we will discuss the role of IL-22 in several CTDs, such as system lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, systemic sclerosis and dermatomyositis, suggesting that IL-22 may be a potential therapeutic target in CTDs. |
topic |
Connective tissue diseases Interleukin-22 Cytokine IL-22R Signalling pathway |
url |
https://doi.org/10.1186/s13578-020-00504-1 |
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