Distinct pre-initiation steps in human mitochondrial translation

Distinct pre-initiation steps in human mitochondrial translation

Translation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the roles of mitochondria-specific ribosomal proteins and...

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Main Authors: Anas Khawaja, Yuzuru Itoh, Cristina Remes, Henrik Spåhr, Olessya Yukhnovets, Henning Höfig, Alexey Amunts, Joanna Rorbach
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16503-2
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spelling doaj-c511e0e642764f37845e6699bdca49702021-06-13T11:18:28ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16503-2Distinct pre-initiation steps in human mitochondrial translationAnas Khawaja0Yuzuru Itoh1Cristina Remes2Henrik Spåhr3Olessya Yukhnovets4Henning Höfig5Alexey Amunts6Joanna Rorbach7Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, BiomedicumDepartment of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, BiomedicumDepartment of Mitochondrial Biology, Max-Planck-Institute for Biology of AgeingDepartment of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, BiomedicumRWTH Aachen, I. Physikalisches Institut (IA)RWTH Aachen, I. Physikalisches Institut (IA)Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, BiomedicumDepartment of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, BiomedicumTranslation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the roles of mitochondria-specific ribosomal proteins and initiation factors mtIF2 and mtIF3.https://doi.org/10.1038/s41467-020-16503-2
collection DOAJ
language English
format Article
sources DOAJ
author Anas Khawaja
Yuzuru Itoh
Cristina Remes
Henrik Spåhr
Olessya Yukhnovets
Henning Höfig
Alexey Amunts
Joanna Rorbach
spellingShingle Anas Khawaja
Yuzuru Itoh
Cristina Remes
Henrik Spåhr
Olessya Yukhnovets
Henning Höfig
Alexey Amunts
Joanna Rorbach
Distinct pre-initiation steps in human mitochondrial translation
Nature Communications
author_facet Anas Khawaja
Yuzuru Itoh
Cristina Remes
Henrik Spåhr
Olessya Yukhnovets
Henning Höfig
Alexey Amunts
Joanna Rorbach
author_sort Anas Khawaja
title Distinct pre-initiation steps in human mitochondrial translation
title_short Distinct pre-initiation steps in human mitochondrial translation
title_full Distinct pre-initiation steps in human mitochondrial translation
title_fullStr Distinct pre-initiation steps in human mitochondrial translation
title_full_unstemmed Distinct pre-initiation steps in human mitochondrial translation
title_sort distinct pre-initiation steps in human mitochondrial translation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Translation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the roles of mitochondria-specific ribosomal proteins and initiation factors mtIF2 and mtIF3.
url https://doi.org/10.1038/s41467-020-16503-2
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AT olessyayukhnovets distinctpreinitiationstepsinhumanmitochondrialtranslation
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