rGO/Silk Fibroin-Modified Nanofibrous Patches Prevent Ventricular Remodeling via Yap/Taz-TGFβ1/Smads Signaling After Myocardial Infarction in Rats

rGO/Silk Fibroin-Modified Nanofibrous Patches Prevent Ventricular Remodeling via Yap/Taz-TGFβ1/Smads Signaling After Myocardial Infarction in Rats

Objective: After acute myocardial infarction (AMI), the loss of cardiomyocytes and dysregulation of extracellular matrix homeostasis results in impaired cardiac function and eventually heart failure. Cardiac patches have emerged as a potential therapeutic strategy for AMI. In this study, we fabricat...

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Bibliographic Details
Main Authors: Yanjing Feng, Guoxu Zhao, Min Xu, Xin Xing, Lijun Yang, Yao Ma, Mengyao Qi, Xiaohui Zhang, Dengfeng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
reduced graphene oxide
acute myocardial infarction
myocardial fibrosis
cardiofibroblasts
YAP/TAZ-TGFβ1/Smads signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.718055/full

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