Sleep disturbances in patients with Parkinson's disease

Introduction Sleep problems, common in Parkinson's disease (PD), are the consequence of the neurodegenerative process, as well as of neurochemical changes on one side, and of drug intake on the other side. Objective To estimate the frequency of sleep problems and its correlation with the diseas...

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Main Author: Smiljković Tatjana
Format: Article
Language:English
Published: Serbian Medical Society 2010-01-01
Series:Srpski Arhiv za Celokupno Lekarstvo
Subjects:
Online Access:http://www.doiserbia.nb.rs/img/doi/0370-8179/2010/0370-81791006274S.pdf
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spelling doaj-c5252c2a20bb41cb9ed63845c01337f62021-01-02T12:32:23ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792010-01-011385-627427810.2298/SARH1006274SSleep disturbances in patients with Parkinson's diseaseSmiljković TatjanaIntroduction Sleep problems, common in Parkinson's disease (PD), are the consequence of the neurodegenerative process, as well as of neurochemical changes on one side, and of drug intake on the other side. Objective To estimate the frequency of sleep problems and its correlation with the disease, therapy and demographic factors in patients with idiopathic Parkinson's disease. Methods The study enrolled 65 consecutive patients who fulfilled criteria for idiopathic PD. The original questionnaire was performed to obtain demographic, disease and treatment data. The patients were tested with standardized scales: unified PD rating scale (UPDRS) and Hoehn and Yahr staging scale (HY scale). Mini mental stage examination (MMSE) was performed for the evaluation of cognitive status. Parkinson's disease sleep scale (PDSS) was applied for the assessment of sleep problems. Results There were 37 male and 28 female patients. Negative correlations (p<0.01) were found between mean total PDSS and mean total UPDRS, as well as the mean scores of each part of UPDRS and HY stage. There was no difference in PDSS scores regarding gender. Analyzing each item in the PDSS scale, the lowest score was obtained for item 8 (nocturia). We did not find any difference in total PDSS scores between the patients on d-agonist and those who did not take d-agonist. Regarding amantadin, intake there were differences between groups for items concerning nocturnal motor symptoms. Conclusion Patients in advanced stages of the disease and worse motility have more prominent sleep problems. Drug therapy has important impact on sleep quality in patients with PD. . http://www.doiserbia.nb.rs/img/doi/0370-8179/2010/0370-81791006274S.pdfParkinson's diseasesleep qualitynocturia
collection DOAJ
language English
format Article
sources DOAJ
author Smiljković Tatjana
spellingShingle Smiljković Tatjana
Sleep disturbances in patients with Parkinson's disease
Srpski Arhiv za Celokupno Lekarstvo
Parkinson's disease
sleep quality
nocturia
author_facet Smiljković Tatjana
author_sort Smiljković Tatjana
title Sleep disturbances in patients with Parkinson's disease
title_short Sleep disturbances in patients with Parkinson's disease
title_full Sleep disturbances in patients with Parkinson's disease
title_fullStr Sleep disturbances in patients with Parkinson's disease
title_full_unstemmed Sleep disturbances in patients with Parkinson's disease
title_sort sleep disturbances in patients with parkinson's disease
publisher Serbian Medical Society
series Srpski Arhiv za Celokupno Lekarstvo
issn 0370-8179
publishDate 2010-01-01
description Introduction Sleep problems, common in Parkinson's disease (PD), are the consequence of the neurodegenerative process, as well as of neurochemical changes on one side, and of drug intake on the other side. Objective To estimate the frequency of sleep problems and its correlation with the disease, therapy and demographic factors in patients with idiopathic Parkinson's disease. Methods The study enrolled 65 consecutive patients who fulfilled criteria for idiopathic PD. The original questionnaire was performed to obtain demographic, disease and treatment data. The patients were tested with standardized scales: unified PD rating scale (UPDRS) and Hoehn and Yahr staging scale (HY scale). Mini mental stage examination (MMSE) was performed for the evaluation of cognitive status. Parkinson's disease sleep scale (PDSS) was applied for the assessment of sleep problems. Results There were 37 male and 28 female patients. Negative correlations (p<0.01) were found between mean total PDSS and mean total UPDRS, as well as the mean scores of each part of UPDRS and HY stage. There was no difference in PDSS scores regarding gender. Analyzing each item in the PDSS scale, the lowest score was obtained for item 8 (nocturia). We did not find any difference in total PDSS scores between the patients on d-agonist and those who did not take d-agonist. Regarding amantadin, intake there were differences between groups for items concerning nocturnal motor symptoms. Conclusion Patients in advanced stages of the disease and worse motility have more prominent sleep problems. Drug therapy has important impact on sleep quality in patients with PD. .
topic Parkinson's disease
sleep quality
nocturia
url http://www.doiserbia.nb.rs/img/doi/0370-8179/2010/0370-81791006274S.pdf
work_keys_str_mv AT smiljkovictatjana sleepdisturbancesinpatientswithparkinsonsdisease
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