The predictive utility of circulating PCSK9 levels on diabetes mellitus
Abstract Increasing data including ours have suggested that proprotein convertase subtilisin/kexin type 9 (PCSK9), a novel regulator of cholesterol metabolism, may also play an important role in the development of type 2 diabetes mellitus (T2DM) and is associated with clinical outcomes in diabetic p...
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Online Access: | https://doi.org/10.1186/s12933-021-01226-5 |
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doaj-c52cbcd859f04cd5854e6fd58687c1872021-02-14T12:26:05ZengBMCCardiovascular Diabetology1475-28402021-02-012011310.1186/s12933-021-01226-5The predictive utility of circulating PCSK9 levels on diabetes mellitusJia Peng0Cheng-Gang Zhu1Jian-Jun Li2State Key Laboratory of Cardiovascular Diseases, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Diseases, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Diseases, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Increasing data including ours have suggested that proprotein convertase subtilisin/kexin type 9 (PCSK9), a novel regulator of cholesterol metabolism, may also play an important role in the development of type 2 diabetes mellitus (T2DM) and is associated with clinical outcomes in diabetic patients. Previous studies revealed that elevated plasma PCSK9 levels had a higher incidence of new-onset T2DM. Moreover, the results of available epidemiological, preclinical, and clinical studies have indicated that plasma PCSK9 concentration is correlated with glycemic parameters and can predict the adverse cardiovascular events in diabetic patients with coronary artery disease. However, there is currently no general agreement about the association of PCSK9 with T2DM. The usefulness of the circulating PCSK9 concentration as a predictor for the risk of new-onset T2DM should be clinically prudential.https://doi.org/10.1186/s12933-021-01226-5Proprotein convertase subtilisin/kexin type 9Type 2 diabetes mellitusRisks |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jia Peng Cheng-Gang Zhu Jian-Jun Li |
spellingShingle |
Jia Peng Cheng-Gang Zhu Jian-Jun Li The predictive utility of circulating PCSK9 levels on diabetes mellitus Cardiovascular Diabetology Proprotein convertase subtilisin/kexin type 9 Type 2 diabetes mellitus Risks |
author_facet |
Jia Peng Cheng-Gang Zhu Jian-Jun Li |
author_sort |
Jia Peng |
title |
The predictive utility of circulating PCSK9 levels on diabetes mellitus |
title_short |
The predictive utility of circulating PCSK9 levels on diabetes mellitus |
title_full |
The predictive utility of circulating PCSK9 levels on diabetes mellitus |
title_fullStr |
The predictive utility of circulating PCSK9 levels on diabetes mellitus |
title_full_unstemmed |
The predictive utility of circulating PCSK9 levels on diabetes mellitus |
title_sort |
predictive utility of circulating pcsk9 levels on diabetes mellitus |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2021-02-01 |
description |
Abstract Increasing data including ours have suggested that proprotein convertase subtilisin/kexin type 9 (PCSK9), a novel regulator of cholesterol metabolism, may also play an important role in the development of type 2 diabetes mellitus (T2DM) and is associated with clinical outcomes in diabetic patients. Previous studies revealed that elevated plasma PCSK9 levels had a higher incidence of new-onset T2DM. Moreover, the results of available epidemiological, preclinical, and clinical studies have indicated that plasma PCSK9 concentration is correlated with glycemic parameters and can predict the adverse cardiovascular events in diabetic patients with coronary artery disease. However, there is currently no general agreement about the association of PCSK9 with T2DM. The usefulness of the circulating PCSK9 concentration as a predictor for the risk of new-onset T2DM should be clinically prudential. |
topic |
Proprotein convertase subtilisin/kexin type 9 Type 2 diabetes mellitus Risks |
url |
https://doi.org/10.1186/s12933-021-01226-5 |
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