Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
Abstract To evaluate extralesional microvascular and structural changes of the macula using optical coherence tomography angiography (OCTA) and structural OCT in cytomegalovirus retinitis (CMVR). An observational study of CMVR patients were performed. Complete ophthalmic examination, serial color fu...
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doaj-c52e4330a059474db2410fd331ef1f982020-12-13T12:31:30ZengNature Publishing GroupScientific Reports2045-23222020-12-011011810.1038/s41598-020-78587-6Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitisNida Wongchaisuwat0Sansanee Khongpipatchaisiri1Sutasinee Boonsopon2Pitipol Choopong3Nattaporn Tesavibul4Supalert Prakhunhungsit5Somanus Thoongsuwan6Nuttawut Rodanant7Nopasak Phasukkijwatana8Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract To evaluate extralesional microvascular and structural changes of the macula using optical coherence tomography angiography (OCTA) and structural OCT in cytomegalovirus retinitis (CMVR). An observational study of CMVR patients were performed. Complete ophthalmic examination, serial color fundus photography, structural OCT and OCTA were performed at baseline and follow-up visits for up to 12 months. The structural OCT was analyzed to evaluate macular areas within, bordering and beyond the CMVR lesions. Extralesional retinal capillary plexus of the macula were evaluated by OCT angiography and compared with the unaffected fellow eyes. Thirteen eyes from 13 patients were enrolled. At baseline, macular areas without CMVR lesions showed decreased vessel density (VD) of both the superficial (P = 0.0002) and deep (P < 0.0001) retinal capillary plexus in eyes with CMVR as compared with the corresponding macular areas of the unaffected fellow eyes. The decrease of VD persisted through the follow-up period for up to 12 months after adjusting for degree of vitreous haze. Structural macular OCT characteristics at the borders and beyond the lesions included intraretinal hyperreflective dots, cystoid macular edema, subretinal fluid and selective ellipsoid zone (EZ) loss. The selective EZ loss found in 6 of 12 eyes showed recovery in 4 eyes after receiving anti-viral treatment. In CMVR eyes, there were microvascular and microstructural abnormalities in the macular area without clinically visible CMVR lesions. Our results provided interesting insights into CMV infection of the retina.https://doi.org/10.1038/s41598-020-78587-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nida Wongchaisuwat Sansanee Khongpipatchaisiri Sutasinee Boonsopon Pitipol Choopong Nattaporn Tesavibul Supalert Prakhunhungsit Somanus Thoongsuwan Nuttawut Rodanant Nopasak Phasukkijwatana |
spellingShingle |
Nida Wongchaisuwat Sansanee Khongpipatchaisiri Sutasinee Boonsopon Pitipol Choopong Nattaporn Tesavibul Supalert Prakhunhungsit Somanus Thoongsuwan Nuttawut Rodanant Nopasak Phasukkijwatana Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis Scientific Reports |
author_facet |
Nida Wongchaisuwat Sansanee Khongpipatchaisiri Sutasinee Boonsopon Pitipol Choopong Nattaporn Tesavibul Supalert Prakhunhungsit Somanus Thoongsuwan Nuttawut Rodanant Nopasak Phasukkijwatana |
author_sort |
Nida Wongchaisuwat |
title |
Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis |
title_short |
Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis |
title_full |
Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis |
title_fullStr |
Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis |
title_full_unstemmed |
Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis |
title_sort |
extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-12-01 |
description |
Abstract To evaluate extralesional microvascular and structural changes of the macula using optical coherence tomography angiography (OCTA) and structural OCT in cytomegalovirus retinitis (CMVR). An observational study of CMVR patients were performed. Complete ophthalmic examination, serial color fundus photography, structural OCT and OCTA were performed at baseline and follow-up visits for up to 12 months. The structural OCT was analyzed to evaluate macular areas within, bordering and beyond the CMVR lesions. Extralesional retinal capillary plexus of the macula were evaluated by OCT angiography and compared with the unaffected fellow eyes. Thirteen eyes from 13 patients were enrolled. At baseline, macular areas without CMVR lesions showed decreased vessel density (VD) of both the superficial (P = 0.0002) and deep (P < 0.0001) retinal capillary plexus in eyes with CMVR as compared with the corresponding macular areas of the unaffected fellow eyes. The decrease of VD persisted through the follow-up period for up to 12 months after adjusting for degree of vitreous haze. Structural macular OCT characteristics at the borders and beyond the lesions included intraretinal hyperreflective dots, cystoid macular edema, subretinal fluid and selective ellipsoid zone (EZ) loss. The selective EZ loss found in 6 of 12 eyes showed recovery in 4 eyes after receiving anti-viral treatment. In CMVR eyes, there were microvascular and microstructural abnormalities in the macular area without clinically visible CMVR lesions. Our results provided interesting insights into CMV infection of the retina. |
url |
https://doi.org/10.1038/s41598-020-78587-6 |
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