Basic principles for the treatment of chronic rhinosinusitis with nasal polyps
Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is based on a chronic inflammatory hyperplastic process in the mucosa membrane of the nasal cavity and paranasal sinuses (SNPs). According to the consensus on the biological treatment of CRSwNP with or without asthma, which is one of th...
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Remedium Group LLC
2020-11-01
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doaj-c52e5e7e647f429ea1d46cceb69ddf472021-07-28T13:29:47ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902020-11-01016737810.21518/2079-701X-2020-16-73-785315Basic principles for the treatment of chronic rhinosinusitis with nasal polypsE. L. Savlevich0V. A. Cherenkova1A. Yu. Molodnitskaia2Central State Medical AcademyCentral State Medical AcademyCentral State Medical AcademyIntroduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is based on a chronic inflammatory hyperplastic process in the mucosa membrane of the nasal cavity and paranasal sinuses (SNPs). According to the consensus on the biological treatment of CRSwNP with or without asthma, which is one of the latest consensus documents of the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), which was published in December 2019, the need for surgical treatment or systemic administration of corticosteroids due to the active nasal polyps growth are conditional signs for the decompensation of clinical control. Currently, the basic treatment for patients with CRSwNP is the long-term use of intranasal corticosteroids (INCS), which leads to an improvement in the quality of life, while minimizing the risk of exacerbations and complications.Research purpose. To evaluate the effectiveness of the basic therapy of intranasal glucocorticosteroid mometasone furoate for different phenotypes of CRSwNP.Methods. All patients with recurrent CRSwNP were divided into 3 equal phenotypic groups of 40 people each: group 1 – CRSwNP without asthma and respiratory allergies, group 2 – CRSwNP + atopy, group 3 – CRSwNP + non-allergic asthma. The observation period was 3 years.Results. Using the algorithm of stepwise therapy of CRSwNP, dynamic monitoring of these patients by an ENT and an allergistimmunologist, basic therapy with corticosteroids with constant treatment correction once every 3 months, it was possible to stabilize the inflammatory process throughout the respiratory tract and reduce the need for surgical treatment.Conclusion. With CRSwNP, long-term use of Mometasone furoate INCS is the main drug of basic therapy to minimize the recurrence of nasal polyp growth and is accompanied by clinical efficacy and the absence of adverse side effects.https://www.med-sovet.pro/jour/article/view/5847polypoid rhinosinusitistherapyintranasal glucocorticosteroidscytokinesmometasone furoate |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. L. Savlevich V. A. Cherenkova A. Yu. Molodnitskaia |
spellingShingle |
E. L. Savlevich V. A. Cherenkova A. Yu. Molodnitskaia Basic principles for the treatment of chronic rhinosinusitis with nasal polyps Медицинский совет polypoid rhinosinusitis therapy intranasal glucocorticosteroids cytokines mometasone furoate |
author_facet |
E. L. Savlevich V. A. Cherenkova A. Yu. Molodnitskaia |
author_sort |
E. L. Savlevich |
title |
Basic principles for the treatment of chronic rhinosinusitis with nasal polyps |
title_short |
Basic principles for the treatment of chronic rhinosinusitis with nasal polyps |
title_full |
Basic principles for the treatment of chronic rhinosinusitis with nasal polyps |
title_fullStr |
Basic principles for the treatment of chronic rhinosinusitis with nasal polyps |
title_full_unstemmed |
Basic principles for the treatment of chronic rhinosinusitis with nasal polyps |
title_sort |
basic principles for the treatment of chronic rhinosinusitis with nasal polyps |
publisher |
Remedium Group LLC |
series |
Медицинский совет |
issn |
2079-701X 2658-5790 |
publishDate |
2020-11-01 |
description |
Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is based on a chronic inflammatory hyperplastic process in the mucosa membrane of the nasal cavity and paranasal sinuses (SNPs). According to the consensus on the biological treatment of CRSwNP with or without asthma, which is one of the latest consensus documents of the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), which was published in December 2019, the need for surgical treatment or systemic administration of corticosteroids due to the active nasal polyps growth are conditional signs for the decompensation of clinical control. Currently, the basic treatment for patients with CRSwNP is the long-term use of intranasal corticosteroids (INCS), which leads to an improvement in the quality of life, while minimizing the risk of exacerbations and complications.Research purpose. To evaluate the effectiveness of the basic therapy of intranasal glucocorticosteroid mometasone furoate for different phenotypes of CRSwNP.Methods. All patients with recurrent CRSwNP were divided into 3 equal phenotypic groups of 40 people each: group 1 – CRSwNP without asthma and respiratory allergies, group 2 – CRSwNP + atopy, group 3 – CRSwNP + non-allergic asthma. The observation period was 3 years.Results. Using the algorithm of stepwise therapy of CRSwNP, dynamic monitoring of these patients by an ENT and an allergistimmunologist, basic therapy with corticosteroids with constant treatment correction once every 3 months, it was possible to stabilize the inflammatory process throughout the respiratory tract and reduce the need for surgical treatment.Conclusion. With CRSwNP, long-term use of Mometasone furoate INCS is the main drug of basic therapy to minimize the recurrence of nasal polyp growth and is accompanied by clinical efficacy and the absence of adverse side effects. |
topic |
polypoid rhinosinusitis therapy intranasal glucocorticosteroids cytokines mometasone furoate |
url |
https://www.med-sovet.pro/jour/article/view/5847 |
work_keys_str_mv |
AT elsavlevich basicprinciplesforthetreatmentofchronicrhinosinusitiswithnasalpolyps AT vacherenkova basicprinciplesforthetreatmentofchronicrhinosinusitiswithnasalpolyps AT ayumolodnitskaia basicprinciplesforthetreatmentofchronicrhinosinusitiswithnasalpolyps |
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