Berberine Suppresses TNF-α-induced MMP-9 and Cell Invasion through Inhibition of AP-1 Activity in MDA-MB-231 Human Breast Cancer Cells

Berberine Suppresses TNF-α-induced MMP-9 and Cell Invasion through Inhibition of AP-1 Activity in MDA-MB-231 Human Breast Cancer Cells

Invasion of cancer cell induced by matrix metalloproteinase-9 (MMP-9) is one of pivotal steps in cancer metastasis. Herein, we investigated how cell invasion was regulated by berberine (BBR), an isoquinoline derivative alkaloid compound, in MDA-MB-231 human breast cancer cells. The basal level of MM...

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Bibliographic Details
Main Authors: Jae Hyuck Choi, Jong Bin Kim, Seok Jin Nam, Jung-Hyun Yang, Jung-Han Kim, Jeong Eon Lee, Sangmin Kim
Format: Article
Language:English
Published: MDPI AG 2008-12-01
Series:Molecules
Subjects:
Berberine
AP-1
MMP-9
Cell invasion
Online Access:http://www.mdpi.com/1420-3049/13/12/2975/

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