Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis

• Main Authors: U V Kharlamova, O E Il'icheva
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2013-03-01
• Series: Терапевтический архив
• Subjects: homocysteine; hemodialysis; left ventricular remodeling
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31249
• ISSN: 0040-3660; 2309-5342

AIM: To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis/MATERIAL AND METHODS: 109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients/RESULTS: In the patients on programmed hemodialysis, Hc concentrations were significantly higher than in apparently healthy individuals; there was a preponderance of mild (49.5%) and moderate (43.1%) hyperhomocysteinemia. LV hypertrophy was diagnosed in 90.8% of the patients. A positive relationship was found between the concentrations of Hc and the E/A ratio (r=0.34; р=0.05), isovolumetric relaxation time (IRT) (r=0.32; р=0.03), and LV mass (LVM) (r=0.3; p=0.05). Multivariate regression analysis indicated that the level of Hc had an independent impact on the E peak (R2=0.3; р=0.05), LV relative wall thickness (RWT) (R2=0.38; р=0.03), and LV IRT (R2=0.3; р=0.06)/CONCLUSION: Elevated plasma Hc levels were found to be related to LVM, LV RWT, LV IRT, E peak, and E/A ratio, suggesting that Hc had an unfavorable effect on the LV structure and function in patients on hemodialysis.