Switchable stimulated Raman scattering microscopy with photochromic vibrational probes

Probes with reversible fluorescence are useful in super-resolution microscopy, but lack sufficient chemical specificity. Here, the authors engineer alkyne tagged diarylethene to realize photo-switchable stimulated Raman scattering probes with high chemical resolution, for applications in living cell...

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Main Authors:	Jianpeng Ao, Xiaofeng Fang, Xianchong Miao, Jiwei Ling, Hyunchul Kang, Sungnam Park, Changfeng Wu, Minbiao Ji
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23407-2

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spelling	doaj-c5313c376b384dc4ba4f35c784df37312021-05-30T11:14:38ZengNature Publishing GroupNature Communications2041-17232021-05-011211810.1038/s41467-021-23407-2Switchable stimulated Raman scattering microscopy with photochromic vibrational probesJianpeng Ao0Xiaofeng Fang1Xianchong Miao2Jiwei Ling3Hyunchul Kang4Sungnam Park5Changfeng Wu6Minbiao Ji7State Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Multiscale Research Institute of Complex Systems, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan UniversityDepartment of Biomedical Engineering, Southern University of Science and TechnologyState Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Multiscale Research Institute of Complex Systems, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan UniversityState Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Multiscale Research Institute of Complex Systems, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan UniversityDepartment of Chemistry and Research Institute for Natural Science, Korea UniversityDepartment of Chemistry and Research Institute for Natural Science, Korea UniversityDepartment of Biomedical Engineering, Southern University of Science and TechnologyState Key Laboratory of Surface Physics and Department of Physics, Human Phenome Institute, Multiscale Research Institute of Complex Systems, Academy for Engineering and Technology, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Fudan UniversityProbes with reversible fluorescence are useful in super-resolution microscopy, but lack sufficient chemical specificity. Here, the authors engineer alkyne tagged diarylethene to realize photo-switchable stimulated Raman scattering probes with high chemical resolution, for applications in living cells.https://doi.org/10.1038/s41467-021-23407-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jianpeng Ao Xiaofeng Fang Xianchong Miao Jiwei Ling Hyunchul Kang Sungnam Park Changfeng Wu Minbiao Ji
spellingShingle	Jianpeng Ao Xiaofeng Fang Xianchong Miao Jiwei Ling Hyunchul Kang Sungnam Park Changfeng Wu Minbiao Ji Switchable stimulated Raman scattering microscopy with photochromic vibrational probes Nature Communications
author_facet	Jianpeng Ao Xiaofeng Fang Xianchong Miao Jiwei Ling Hyunchul Kang Sungnam Park Changfeng Wu Minbiao Ji
author_sort	Jianpeng Ao
title	Switchable stimulated Raman scattering microscopy with photochromic vibrational probes
title_short	Switchable stimulated Raman scattering microscopy with photochromic vibrational probes
title_full	Switchable stimulated Raman scattering microscopy with photochromic vibrational probes
title_fullStr	Switchable stimulated Raman scattering microscopy with photochromic vibrational probes
title_full_unstemmed	Switchable stimulated Raman scattering microscopy with photochromic vibrational probes
title_sort	switchable stimulated raman scattering microscopy with photochromic vibrational probes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-05-01
description	Probes with reversible fluorescence are useful in super-resolution microscopy, but lack sufficient chemical specificity. Here, the authors engineer alkyne tagged diarylethene to realize photo-switchable stimulated Raman scattering probes with high chemical resolution, for applications in living cells.
url	https://doi.org/10.1038/s41467-021-23407-2
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Switchable stimulated Raman scattering microscopy with photochromic vibrational probes

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