Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation
Most of the neurological disorders in the brain are caused by the abnormal buildup of misfolded or aggregated proteins. Osmolytes are low molecular weight organic molecules usually built up in tissues at a quite high amount during stress or any pathological condition. These molecules help in providi...
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doaj-c5374506686b4bddaffdc10c2bde10fb2020-11-25T01:32:46ZengMDPI AGBiomolecules2218-273X2020-01-0110113210.3390/biom10010132biom10010132Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and AggregationNeetu Kushwah0Vishal Jain1Dhananjay Yadav2Functional Genomics Unit, CSIR-institute of genomics and integrative biology, Mall road, Delhi 110007, IndiaDepartment of ECE, Carnegie Mellon University, Pittsburgh, PA 15289, USADepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 712-749, KoreaMost of the neurological disorders in the brain are caused by the abnormal buildup of misfolded or aggregated proteins. Osmolytes are low molecular weight organic molecules usually built up in tissues at a quite high amount during stress or any pathological condition. These molecules help in providing stability to the aggregated proteins and protect these proteins from misfolding. Alzheimer’s disease (AD) is the uttermost universal neurological disorder that can be described by the deposition of neurofibrillary tangles, aggregated/misfolded protein produced by the amyloid β-protein (Aβ). Osmolytes provide stability to the folded, functional form of a protein and alter the folding balance away from aggregation and/or degradation of the protein. Moreover, they are identified as chemical chaperones. Brain osmolytes enhance the pace of Aβ aggregation, combine with the nearby water molecules more promptly, and avert the aggregation/misfolding of proteins by providing stability to them. Therefore, osmolytes can be employed as therapeutic targets and may assist in potential drug design for many neurodegenerative and other diseases.https://www.mdpi.com/2218-273X/10/1/132osmolytesalzheimer’sprotein folding/misfoldingaβ aggregation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neetu Kushwah Vishal Jain Dhananjay Yadav |
spellingShingle |
Neetu Kushwah Vishal Jain Dhananjay Yadav Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation Biomolecules osmolytes alzheimer’s protein folding/misfolding aβ aggregation |
author_facet |
Neetu Kushwah Vishal Jain Dhananjay Yadav |
author_sort |
Neetu Kushwah |
title |
Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation |
title_short |
Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation |
title_full |
Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation |
title_fullStr |
Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation |
title_full_unstemmed |
Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation |
title_sort |
osmolytes: a possible therapeutic molecule for ameliorating the neurodegeneration caused by protein misfolding and aggregation |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2020-01-01 |
description |
Most of the neurological disorders in the brain are caused by the abnormal buildup of misfolded or aggregated proteins. Osmolytes are low molecular weight organic molecules usually built up in tissues at a quite high amount during stress or any pathological condition. These molecules help in providing stability to the aggregated proteins and protect these proteins from misfolding. Alzheimer’s disease (AD) is the uttermost universal neurological disorder that can be described by the deposition of neurofibrillary tangles, aggregated/misfolded protein produced by the amyloid β-protein (Aβ). Osmolytes provide stability to the folded, functional form of a protein and alter the folding balance away from aggregation and/or degradation of the protein. Moreover, they are identified as chemical chaperones. Brain osmolytes enhance the pace of Aβ aggregation, combine with the nearby water molecules more promptly, and avert the aggregation/misfolding of proteins by providing stability to them. Therefore, osmolytes can be employed as therapeutic targets and may assist in potential drug design for many neurodegenerative and other diseases. |
topic |
osmolytes alzheimer’s protein folding/misfolding aβ aggregation |
url |
https://www.mdpi.com/2218-273X/10/1/132 |
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