Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging
The lateral ventricular perimeter (LVP) of the brain is a critical region because in addition to housing neural stem cells required for brain development, it facilitates cerebrospinal fluid (CSF) bulk flow and functions as a blood-CSF barrier to protect periventricular white matter (PVWM) and other...
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doaj-c5386d9faebe4ab0b21142caf32799d22021-01-02T05:10:49ZengElsevierMethodsX2215-01612020-01-017101023Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imagingAlbert M. Isaacs0Rowland H. Han1Christopher D. Smyser2David D. Limbrick, Jr.3Joshua S. Shimony4Corresponding author at: Department of Biology and Biomedical Sciences, Washington University School of Medicine 425 S Euclid Ave, St. Louis, MO 63110, USA; Department of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, CanadaDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USADepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USAMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USAThe lateral ventricular perimeter (LVP) of the brain is a critical region because in addition to housing neural stem cells required for brain development, it facilitates cerebrospinal fluid (CSF) bulk flow and functions as a blood-CSF barrier to protect periventricular white matter (PVWM) and other adjacent regions from injurious toxins. LVP injury is common, particularly among preterm infants who sustain intraventricular hemorrhage or post hemorrhagic hydrocephalus and has been associated with poor neurological outcomes. Assessment of the LVP with diffusion MRI has been challenging, primarily due to issues with partial volume artifacts since the LVP region is in close proximity to CSF and other structures of varying signal intensities that may be inadvertently included in LVP segmentation.This research method presents: • A novel MATLAB-based method to segment a homogenous LVP layer using high spatial resolution parameters (voxel size 1.2 × 1.2 × 1.2 mm3) to only capture the innermost layer of the LVP. • The segmented LVP is averaged from three contiguous axial slices to increase signal to noise ratio and reduce the effect of any residual volume averaging effect and eliminates manual and inter/intrarater-related errors.http://www.sciencedirect.com/science/article/pii/S2215016120302430Segmentation of lateral ventricular perimeter regions of interest |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Albert M. Isaacs Rowland H. Han Christopher D. Smyser David D. Limbrick, Jr. Joshua S. Shimony |
spellingShingle |
Albert M. Isaacs Rowland H. Han Christopher D. Smyser David D. Limbrick, Jr. Joshua S. Shimony Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging MethodsX Segmentation of lateral ventricular perimeter regions of interest |
author_facet |
Albert M. Isaacs Rowland H. Han Christopher D. Smyser David D. Limbrick, Jr. Joshua S. Shimony |
author_sort |
Albert M. Isaacs |
title |
Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging |
title_short |
Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging |
title_full |
Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging |
title_fullStr |
Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging |
title_full_unstemmed |
Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging |
title_sort |
semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging |
publisher |
Elsevier |
series |
MethodsX |
issn |
2215-0161 |
publishDate |
2020-01-01 |
description |
The lateral ventricular perimeter (LVP) of the brain is a critical region because in addition to housing neural stem cells required for brain development, it facilitates cerebrospinal fluid (CSF) bulk flow and functions as a blood-CSF barrier to protect periventricular white matter (PVWM) and other adjacent regions from injurious toxins. LVP injury is common, particularly among preterm infants who sustain intraventricular hemorrhage or post hemorrhagic hydrocephalus and has been associated with poor neurological outcomes. Assessment of the LVP with diffusion MRI has been challenging, primarily due to issues with partial volume artifacts since the LVP region is in close proximity to CSF and other structures of varying signal intensities that may be inadvertently included in LVP segmentation.This research method presents: • A novel MATLAB-based method to segment a homogenous LVP layer using high spatial resolution parameters (voxel size 1.2 × 1.2 × 1.2 mm3) to only capture the innermost layer of the LVP. • The segmented LVP is averaged from three contiguous axial slices to increase signal to noise ratio and reduce the effect of any residual volume averaging effect and eliminates manual and inter/intrarater-related errors. |
topic |
Segmentation of lateral ventricular perimeter regions of interest |
url |
http://www.sciencedirect.com/science/article/pii/S2215016120302430 |
work_keys_str_mv |
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