Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening
Objective: Chronic kidney disease (CKD) is a major public health concern worldwide. High costs of late-stage diagnosis and insufficient testing facilities can contribute to high morbidity and mortality rates in CKD patients, particularly in less developed countries. Thus, early diagnosis aided by vi...
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doaj-c538d35f9bc040ee84b733dc6d0e21c12021-04-26T23:00:18ZengIEEEIEEE Journal of Translational Engineering in Health and Medicine2168-23722021-01-01911110.1109/JTEHM.2021.30736299405681Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic ScreeningMd. Rashed-Al-Mahfuz0https://orcid.org/0000-0001-7039-6176Abedul Haque1https://orcid.org/0000-0001-6166-8766Akm Azad2Salem A. Alyami3https://orcid.org/0000-0002-5507-9399Julian M. W. Quinn4https://orcid.org/0000-0001-9674-9646Mohammad Ali Moni5https://orcid.org/0000-0003-0756-1006Department of Computer Science and Engineering, University of Rajshahi, Rajshahi, BangladeshDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAiThree Institute, University of Technology Sydney, NSW, AustraliaDepartment of Mathematics and Statistics, Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi ArabiaBone Biology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, AustraliaWHO Collaborating Centre of eHealth, School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW, AustraliaObjective: Chronic kidney disease (CKD) is a major public health concern worldwide. High costs of late-stage diagnosis and insufficient testing facilities can contribute to high morbidity and mortality rates in CKD patients, particularly in less developed countries. Thus, early diagnosis aided by vital parameter analytics using affordable computer-aided diagnosis could not only reduce diagnosis costs but improve patient management and outcomes. Methods: In this study, we developed machine learning models using selective key pathological categories to identify clinical test attributes that will aid in accurate early diagnosis of CKD. Such an approach will save time and costs for diagnostic screening. We have also evaluated the performance of several classifiers with k-fold cross-validation on optimized datasets derived using these selected clinical test attributes. Results: Our results suggest that the optimized datasets with important attributes perform well in diagnosis of CKD using our proposed machine learning models. Furthermore, we evaluated clinical test attributes based on urine and blood tests along with clinical parameters that have low costs of acquisition. The predictive models with the optimized and pathologically categorized attributes set yielded high levels of CKD diagnosis accuracy with random forest (RF) classifier being the best performing. Conclusions: Our machine learning approach has yielded effective predictive analytics for CKD screening which can be developed as a resource to facilitate improved CKD screening for enhanced and timely treatment plans.https://ieeexplore.ieee.org/document/9405681/Attribute selectionchronic kidney disease (CKD)computer-aided diagnosisexplainable AImachine learning (ML) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Md. Rashed-Al-Mahfuz Abedul Haque Akm Azad Salem A. Alyami Julian M. W. Quinn Mohammad Ali Moni |
spellingShingle |
Md. Rashed-Al-Mahfuz Abedul Haque Akm Azad Salem A. Alyami Julian M. W. Quinn Mohammad Ali Moni Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening IEEE Journal of Translational Engineering in Health and Medicine Attribute selection chronic kidney disease (CKD) computer-aided diagnosis explainable AI machine learning (ML) |
author_facet |
Md. Rashed-Al-Mahfuz Abedul Haque Akm Azad Salem A. Alyami Julian M. W. Quinn Mohammad Ali Moni |
author_sort |
Md. Rashed-Al-Mahfuz |
title |
Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening |
title_short |
Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening |
title_full |
Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening |
title_fullStr |
Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening |
title_full_unstemmed |
Clinically Applicable Machine Learning Approaches to Identify Attributes of Chronic Kidney Disease (CKD) for Use in Low-Cost Diagnostic Screening |
title_sort |
clinically applicable machine learning approaches to identify attributes of chronic kidney disease (ckd) for use in low-cost diagnostic screening |
publisher |
IEEE |
series |
IEEE Journal of Translational Engineering in Health and Medicine |
issn |
2168-2372 |
publishDate |
2021-01-01 |
description |
Objective: Chronic kidney disease (CKD) is a major public health concern worldwide. High costs of late-stage diagnosis and insufficient testing facilities can contribute to high morbidity and mortality rates in CKD patients, particularly in less developed countries. Thus, early diagnosis aided by vital parameter analytics using affordable computer-aided diagnosis could not only reduce diagnosis costs but improve patient management and outcomes. Methods: In this study, we developed machine learning models using selective key pathological categories to identify clinical test attributes that will aid in accurate early diagnosis of CKD. Such an approach will save time and costs for diagnostic screening. We have also evaluated the performance of several classifiers with k-fold cross-validation on optimized datasets derived using these selected clinical test attributes. Results: Our results suggest that the optimized datasets with important attributes perform well in diagnosis of CKD using our proposed machine learning models. Furthermore, we evaluated clinical test attributes based on urine and blood tests along with clinical parameters that have low costs of acquisition. The predictive models with the optimized and pathologically categorized attributes set yielded high levels of CKD diagnosis accuracy with random forest (RF) classifier being the best performing. Conclusions: Our machine learning approach has yielded effective predictive analytics for CKD screening which can be developed as a resource to facilitate improved CKD screening for enhanced and timely treatment plans. |
topic |
Attribute selection chronic kidney disease (CKD) computer-aided diagnosis explainable AI machine learning (ML) |
url |
https://ieeexplore.ieee.org/document/9405681/ |
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