The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics
Introduction: Depressive symptoms may occur in all stages of schizophrenia disorder. Clozapine is the only antipsychotic that has been demonstrated superior efficacy in schizophrenia and suicidal ideation. The aim of this study is to evaluate depressive symptoms in patients with schizophrenia treate...
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doaj-c53c842dc1b04de8b0c717204cdd5ac82021-05-12T07:46:52ZengSERNEVFamily Practice and Palliative Care2458-88652459-15052016-08-0112313410.22391/920.2566891560The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychoticsBurkay Yakar0Mehmet Er1Hatice Yardım Özayhan2Hülya Ertekin3Çorum Gulabibey Aile Sağlığı Merkezi, Çorum, TürkiyeKonya Eğitim ve Araştırma Hastanesi, Beyhekim Psikiyatri Kliniği, Konya, TürkiyeKonya Eğitim ve Araştırma Hastanesi, Beyhekim Psikiyatri Kliniği, Konya, TürkiyeÇanakkale Onsekiz Mart Üniversitesi, Tıp Fakültesi, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı, ÇanakkaleIntroduction: Depressive symptoms may occur in all stages of schizophrenia disorder. Clozapine is the only antipsychotic that has been demonstrated superior efficacy in schizophrenia and suicidal ideation. The aim of this study is to evaluate depressive symptoms in patients with schizophrenia treated with clozapine and to compare with treated with other atypical antipsychotics.Methods: A cross-sectional descriptive study was carried out on patients with schizophrenia according to DSM-IV-TR between December 2012 and May 2013. All participants were evaluated for demographic characteristics and points of Brief Psychiatric Rating Scale, Positive, Negative Syndrome Scale, and Calgary Depression Scale for Schizophrenia.Results: A total 23.6% (n = 13) patients treated with clozapine, while 76.4% (n = 42) patients were treated with other antipsychotic drugs. 23.1% (n = 3) of patients taking clozapine were women, 76.9% (n = 10) were male. The mean age of patients treated with clozapine was 43.0 ± 11.2. The level of depression of patients treated with clozapine was 15.4% (n = 2). No statistically significant difference was found between patients between treated with clozapine and other antipsychotics regarding age, sex, marital status, education years, work history, age at onset of disease, depression and history of suicide attemptConclusion: As a result of this study it is found that clozapine did not effect on the level of depression in patients with schizophrenia, and depression level of patients with schizophrenia treated with clozapine had no difference from patients treated with other antipsychotics.https://dergipark.org.tr/en/pub/fppc/issue/24207/256689atipik antipsikotiklerdepresyonklozapinşizofreniatypical antipsychoticsclozapinedepressionschizophrenia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Burkay Yakar Mehmet Er Hatice Yardım Özayhan Hülya Ertekin |
spellingShingle |
Burkay Yakar Mehmet Er Hatice Yardım Özayhan Hülya Ertekin The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics Family Practice and Palliative Care atipik antipsikotikler depresyon klozapin şizofreni atypical antipsychotics clozapine depression schizophrenia |
author_facet |
Burkay Yakar Mehmet Er Hatice Yardım Özayhan Hülya Ertekin |
author_sort |
Burkay Yakar |
title |
The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics |
title_short |
The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics |
title_full |
The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics |
title_fullStr |
The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics |
title_full_unstemmed |
The effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics |
title_sort |
effects of antipsychotic drugs on depression level in patients with schizophrenia: clozapine vs. other atypical antipsychotics |
publisher |
SERNEV |
series |
Family Practice and Palliative Care |
issn |
2458-8865 2459-1505 |
publishDate |
2016-08-01 |
description |
Introduction: Depressive symptoms may occur in all stages of schizophrenia disorder. Clozapine is the only antipsychotic that has been demonstrated superior efficacy in schizophrenia and suicidal ideation. The aim of this study is to evaluate depressive symptoms in patients with schizophrenia treated with clozapine and to compare with treated with other atypical antipsychotics.Methods: A cross-sectional descriptive study was carried out on patients with schizophrenia according to DSM-IV-TR between December 2012 and May 2013. All participants were evaluated for demographic characteristics and points of Brief Psychiatric Rating Scale, Positive, Negative Syndrome Scale, and Calgary Depression Scale for Schizophrenia.Results: A total 23.6% (n = 13) patients treated with clozapine, while 76.4% (n = 42) patients were treated with other antipsychotic drugs. 23.1% (n = 3) of patients taking clozapine were women, 76.9% (n = 10) were male. The mean age of patients treated with clozapine was 43.0 ± 11.2. The level of depression of patients treated with clozapine was 15.4% (n = 2). No statistically significant difference was found between patients between treated with clozapine and other antipsychotics regarding age, sex, marital status, education years, work history, age at onset of disease, depression and history of suicide attemptConclusion: As a result of this study it is found that clozapine did not effect on the level of depression in patients with schizophrenia, and depression level of patients with schizophrenia treated with clozapine had no difference from patients treated with other antipsychotics. |
topic |
atipik antipsikotikler depresyon klozapin şizofreni atypical antipsychotics clozapine depression schizophrenia |
url |
https://dergipark.org.tr/en/pub/fppc/issue/24207/256689 |
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