Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone–related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells

Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone–related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells

The N-terminus of parathyroid hormone–related protein regulates bone marrow stromal cell differentiation. We hypothesized that the nuclear localization sequence and C-terminus are involved. MicroRNA and gene expression analyses were performed on bone marrow stromal cells from mice lacking the nuclea...

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Bibliographic Details
Main Authors: Blake E Hildreth, Krista M Hernon, Wessel P Dirksen, John Leong, Wachiraphan Supsavhad, Prosper N Boyaka, Thomas J Rosol, Ramiro E Toribio
Format: Article
Language:English
Published: SAGE Publishing 2015-10-01
Series:Journal of Tissue Engineering
Online Access:https://doi.org/10.1177/2041731415609298

Internet

https://doi.org/10.1177/2041731415609298

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