The Effect of Meniran Herbs Extract (Phyllanthus niruri Linn) on The Histological Spectrum of The Uterus and Oviduct Rats (Rattus Norvegicus)

• Main Authors: Rosa Mutianingsih, Khairil Pahmi
• Format: Article
• Language: English
• Published: Universitas Sriwijaya 2020-12-01
• Series: Bioscientia Medicina: Journal of Biomedicine and Translational Research
• Subjects: phyllanthus niruri extract; fibrosis; matrix extracelluer
• Online Access: https://bioscmed.com/index.php/bsm/article/view/211
• ISSN: 2598-0580

A B S T R A C T Background The use of plants as natural medicinal ingredients is increasingly in demand by the public because the plants are considered to have lower negative effects than chemical drugs. The effect of mineran herbs extract (Phyllanthus niruri Linn) on the histological spectrum of the uterus and oviduct rat (Rattus Norvegicus) had been studied.Aim of Study Aim of this study to explore the effect of meniran herbs extract (Phyllanthus niruri Linn) on the histological spectrum of the uterus and oviduct rat (Rattus Norvegicus) Methods Wistar rats have been challenged with 2% NaCl in drinking water to result in fibrotic uterus and oviduct. Phyllanthus niruri extract (200 mg/Kg) turned into given orally for 4 weeks. Matrix extracellular abundance turned into decided via way of means of HE Staining and measured via way of means of METAVIR Fibrosis Score. The result of this examine have been assayed via way of means of SPSS 16. Results P. niruri extract was potent to reduce the matrix extracellular in 2% NaCl-induced rats compared to control group (p<0.05) in uterus. Meanwhile, P. niruri extract was not able to decrease the matrix extracellular in 2% NaCl-induced rats compared to control group (p>0.05) in oviduct. Conclusion P. niruri extract was potent to decrease the matrix extracellular in the uterus of the rats, but in oviduct.