Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial
Introduction: Oral Lichen Planus (OLP) is a chronic immunological, mucocutaneous disease with a wide range of clinical appearances. The treatment of oral lichen planus is often difficult and disappointing. Aim: We have studied the efficacy of curcumin, a low molecular weight flavonoid with anti...
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doaj-c55d5a3682574786a0f5d3baa35e676e2020-11-25T03:34:22ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-05-01105ZC134ZC13710.7860/JCDR/2016/16338.7870Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled TrialMaryam Amirchaghmaghi0Atessa Pakfetrat1Zahra Delavarian2Hanieh Ghalavani3Ala Ghazi4Associate Professor, Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.Specialist of Oral Medicine, Mashhad, Iran.Professor, Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Oral Lichen Planus (OLP) is a chronic immunological, mucocutaneous disease with a wide range of clinical appearances. The treatment of oral lichen planus is often difficult and disappointing. Aim: We have studied the efficacy of curcumin, a low molecular weight flavonoid with anti-inflammatory and anti-oxidant activities, in the treatment of OLP. Materials and Methods: In this study, a randomized, doubleblind, placebo-controlled trial was conducted with a total of 20 OLP patients. The patients were randomly divided into two groups, each treated with curcumin tablets at a dose of 2000 mg/day or placebo for a period of four weeks. Furthermore, the patients of both groups received routine treatment for OLP (i.e. Mouthwash Dexamethasone 0.5 mg and suspension Nystatin 100,000 Units). The baseline data were recorded for each patient. Patients were evaluated on day 14 and after completing the course of treatment. Pain and burning sensation were measured based on the Visual Analogue Scale, and the Thongprasom Index was used for clinical improvement and healing. Mann-Whitney and independent t-test were used to compare the responses between the two groups, p-value < 0.05 was considered statistically significant. Results: Our analyses demonstrated no significant difference between the curcumin and placebo treated groups. Conclusion: In conclusion, curcumin had no detectable effect in the treatment of OLP. However, a higher dose of curcumin administration and other forms of curcumin with improved bioavailability may be considered in future studies. https://jcdr.net/articles/PDF/7870/16338_CE(Ra1)_F(GH)_PF1(EKAK)_PFA(AK)_PF2(ACAK).pdfanti-inflammatoryclinical trialerosive |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maryam Amirchaghmaghi Atessa Pakfetrat Zahra Delavarian Hanieh Ghalavani Ala Ghazi |
spellingShingle |
Maryam Amirchaghmaghi Atessa Pakfetrat Zahra Delavarian Hanieh Ghalavani Ala Ghazi Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial Journal of Clinical and Diagnostic Research anti-inflammatory clinical trial erosive |
author_facet |
Maryam Amirchaghmaghi Atessa Pakfetrat Zahra Delavarian Hanieh Ghalavani Ala Ghazi |
author_sort |
Maryam Amirchaghmaghi |
title |
Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial |
title_short |
Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial |
title_full |
Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial |
title_fullStr |
Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial |
title_full_unstemmed |
Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial |
title_sort |
evaluation of the efficacy of curcumin in the treatment of oral lichen planus: a randomized controlled trial |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-05-01 |
description |
Introduction: Oral Lichen Planus (OLP) is a chronic
immunological, mucocutaneous disease with a wide range of
clinical appearances. The treatment of oral lichen planus is
often difficult and disappointing.
Aim: We have studied the efficacy of curcumin, a low molecular
weight flavonoid with anti-inflammatory and anti-oxidant
activities, in the treatment of OLP.
Materials and Methods: In this study, a randomized, doubleblind, placebo-controlled trial was conducted with a total of
20 OLP patients. The patients were randomly divided into two
groups, each treated with curcumin tablets at a dose of 2000
mg/day or placebo for a period of four weeks. Furthermore,
the patients of both groups received routine treatment for
OLP (i.e. Mouthwash Dexamethasone 0.5 mg and suspension
Nystatin 100,000 Units). The baseline data were recorded for
each patient. Patients were evaluated on day 14 and after
completing the course of treatment. Pain and burning sensation
were measured based on the Visual Analogue Scale, and the
Thongprasom Index was used for clinical improvement and
healing. Mann-Whitney and independent t-test were used to
compare the responses between the two groups, p-value < 0.05
was considered statistically significant.
Results: Our analyses demonstrated no significant difference
between the curcumin and placebo treated groups.
Conclusion: In conclusion, curcumin had no detectable effect
in the treatment of OLP. However, a higher dose of curcumin
administration and other forms of curcumin with improved
bioavailability may be considered in future studies.
|
topic |
anti-inflammatory clinical trial erosive |
url |
https://jcdr.net/articles/PDF/7870/16338_CE(Ra1)_F(GH)_PF1(EKAK)_PFA(AK)_PF2(ACAK).pdf |
work_keys_str_mv |
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