Plasmodium falciparum infection and the risk of anemia in school children
Background According to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum. The purpose of the present study was to determ...
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doaj-c56ce354ce404f7e865e75a7cc772d522020-11-25T02:52:30ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622013-08-01322128134Plasmodium falciparum infection and the risk of anemia in school childrenSuriyani Tan0Taniawati Supali1Heri Wibowo2Department of Parasitology Faculty of Medicine Trisakti University Department of Parasitology Faculty of Medicine University of IndonesiaDepartment of Parasitology Faculty of Medicine University of IndonesiaBackground According to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum. The purpose of the present study was to determine any association between Plasmodium falciparum infection and anemia in school children. Methods This was an observational study with cross-sectional approach. A total of 540 whole blood samples of school children after administration of anthelminthic treatment for 30 days, were collected for measurement of hemoglobin concentration and preparation of Giemsa-stained thin and thick blood smears. The species of Plasmodium was confirmed by real-time polymerase chain reaction (PCR). Chi-square and prevalence ratio (PR) tests were used to determine the relationship between Plasmodium falciparum infection and anemia. Results The prevalence of Plasmodium infection in school children of malarial endemic areas was 3.51%. There were 43 cases of anemia with 41 cases of mild anemia and 2 cases of moderate anemia. Among the 41 mild cases of anemia, Plasmodium falciparum infection was found in only 3 cases. The 2 cases of moderate anemia and the remaining 38 cases of mild anemia were not caused by Plasmodium falciparum infection. Subjects with Plasmodium falciparum infection had a 1.91-fold higher risk of suffering from anemia than subjects without Plasmodium falciparum infection, but not significant (PR=1.91; 95% C.I.=0.65-5.62). Conclusions Plasmodium falciparum infection did not significantly increase the risk of anemia in school children. Efforts to improve strategies for controlling anemia and malaria are needed.http://www.univmed.org/wp-content/uploads/2013/09/Suriyani1.pdfPlasmodium falciparumanemiaschool children |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suriyani Tan Taniawati Supali Heri Wibowo |
spellingShingle |
Suriyani Tan Taniawati Supali Heri Wibowo Plasmodium falciparum infection and the risk of anemia in school children Universa Medicina Plasmodium falciparum anemia school children |
author_facet |
Suriyani Tan Taniawati Supali Heri Wibowo |
author_sort |
Suriyani Tan |
title |
Plasmodium falciparum infection and the risk of anemia in school children |
title_short |
Plasmodium falciparum infection and the risk of anemia in school children |
title_full |
Plasmodium falciparum infection and the risk of anemia in school children |
title_fullStr |
Plasmodium falciparum infection and the risk of anemia in school children |
title_full_unstemmed |
Plasmodium falciparum infection and the risk of anemia in school children |
title_sort |
plasmodium falciparum infection and the risk of anemia in school children |
publisher |
Faculty of Medicine Trisakti University |
series |
Universa Medicina |
issn |
1907-3062 |
publishDate |
2013-08-01 |
description |
Background
According to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum. The purpose of the present study was to determine any association between Plasmodium falciparum infection and anemia in school children.
Methods
This was an observational study with cross-sectional approach. A total of 540 whole blood samples of school children after administration of anthelminthic treatment for 30 days, were collected for measurement of hemoglobin concentration and preparation of Giemsa-stained thin and thick blood smears. The species of Plasmodium was confirmed by real-time polymerase chain reaction (PCR). Chi-square and prevalence ratio (PR) tests were used to determine the relationship between Plasmodium falciparum infection and anemia.
Results
The prevalence of Plasmodium infection in school children of malarial endemic areas was 3.51%. There were 43 cases of anemia with 41 cases of mild anemia and 2 cases of moderate anemia. Among the 41 mild cases of anemia, Plasmodium falciparum infection was found in only 3 cases. The 2 cases of moderate anemia and the remaining 38 cases of mild anemia were not caused by Plasmodium falciparum infection. Subjects with Plasmodium falciparum infection had a 1.91-fold higher risk of suffering from anemia than subjects without Plasmodium falciparum infection, but not significant (PR=1.91; 95% C.I.=0.65-5.62).
Conclusions
Plasmodium falciparum infection did not significantly increase the risk of anemia in school children. Efforts to improve strategies for controlling anemia and malaria are needed. |
topic |
Plasmodium falciparum anemia school children |
url |
http://www.univmed.org/wp-content/uploads/2013/09/Suriyani1.pdf |
work_keys_str_mv |
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