Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus

Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk. Purpose: We assessed serum le...

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Main Authors: Maryam Mardani, Shiva Torabi Ardakani, Ladan Dastgheib, Nasrin Hamidizadeh
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2020-12-01
Series:Journal of Dentistry
Subjects:
Online Access:https://dentjods.sums.ac.ir/article_46238.html
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spelling doaj-c5876d211269429781b26005d14e30762021-01-03T06:04:53ZengShiraz University of Medical SciencesJournal of Dentistry2345-64852345-64182020-12-01214330334Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen PlanusMaryam Mardani 0Shiva Torabi Ardakani 1Ladan Dastgheib 2Nasrin Hamidizadeh 3Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: In this case-control study, peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals in this case-control study. Serum samples were prepared from patients with lichen planus and IL-22 concentration was measured in each serum sample by using a commercial ELISA Kit. The obtained data were then analyzed using the Kruskal-Wallis (one-way ANOVA) test. Results: The IL-22 serum levels were significantly higher in patients with oral lichen planus compared to the healthy control group (p< 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p= 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus. https://dentjods.sums.ac.ir/article_46238.htmlil-22; oral lichen planus; cutaneous lichen planus; serum
collection DOAJ
language English
format Article
sources DOAJ
author Maryam Mardani
Shiva Torabi Ardakani
Ladan Dastgheib
Nasrin Hamidizadeh
spellingShingle Maryam Mardani
Shiva Torabi Ardakani
Ladan Dastgheib
Nasrin Hamidizadeh
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
Journal of Dentistry
il-22; oral lichen planus; cutaneous lichen planus; serum
author_facet Maryam Mardani
Shiva Torabi Ardakani
Ladan Dastgheib
Nasrin Hamidizadeh
author_sort Maryam Mardani
title Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
title_short Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
title_full Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
title_fullStr Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
title_full_unstemmed Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
title_sort serum levels of il-22 in patients with oral lichen planus and cutaneous lichen planus
publisher Shiraz University of Medical Sciences
series Journal of Dentistry
issn 2345-6485
2345-6418
publishDate 2020-12-01
description Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: In this case-control study, peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals in this case-control study. Serum samples were prepared from patients with lichen planus and IL-22 concentration was measured in each serum sample by using a commercial ELISA Kit. The obtained data were then analyzed using the Kruskal-Wallis (one-way ANOVA) test. Results: The IL-22 serum levels were significantly higher in patients with oral lichen planus compared to the healthy control group (p< 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p= 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus.
topic il-22; oral lichen planus; cutaneous lichen planus; serum
url https://dentjods.sums.ac.ir/article_46238.html
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AT shivatorabiardakani serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus
AT ladandastgheib serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus
AT nasrinhamidizadeh serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus
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