Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk. Purpose: We assessed serum le...
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Shiraz University of Medical Sciences
2020-12-01
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doaj-c5876d211269429781b26005d14e30762021-01-03T06:04:53ZengShiraz University of Medical SciencesJournal of Dentistry2345-64852345-64182020-12-01214330334Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen PlanusMaryam Mardani 0Shiva Torabi Ardakani 1Ladan Dastgheib 2Nasrin Hamidizadeh 3Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: In this case-control study, peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals in this case-control study. Serum samples were prepared from patients with lichen planus and IL-22 concentration was measured in each serum sample by using a commercial ELISA Kit. The obtained data were then analyzed using the Kruskal-Wallis (one-way ANOVA) test. Results: The IL-22 serum levels were significantly higher in patients with oral lichen planus compared to the healthy control group (p< 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p= 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus. https://dentjods.sums.ac.ir/article_46238.htmlil-22; oral lichen planus; cutaneous lichen planus; serum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maryam Mardani Shiva Torabi Ardakani Ladan Dastgheib Nasrin Hamidizadeh |
spellingShingle |
Maryam Mardani Shiva Torabi Ardakani Ladan Dastgheib Nasrin Hamidizadeh Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus Journal of Dentistry il-22; oral lichen planus; cutaneous lichen planus; serum |
author_facet |
Maryam Mardani Shiva Torabi Ardakani Ladan Dastgheib Nasrin Hamidizadeh |
author_sort |
Maryam Mardani |
title |
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus |
title_short |
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus |
title_full |
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus |
title_fullStr |
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus |
title_full_unstemmed |
Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus |
title_sort |
serum levels of il-22 in patients with oral lichen planus and cutaneous lichen planus |
publisher |
Shiraz University of Medical Sciences |
series |
Journal of Dentistry |
issn |
2345-6485 2345-6418 |
publishDate |
2020-12-01 |
description |
Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk.
Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals.
Materials and Method: In this case-control study, peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals in this case-control study. Serum samples were prepared from patients with lichen planus and IL-22 concentration was measured in each serum sample by using a commercial ELISA Kit. The obtained data were then analyzed using the Kruskal-Wallis (one-way ANOVA) test.
Results: The IL-22 serum levels were significantly higher in patients with oral lichen planus compared to the healthy control group (p< 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p= 0.183).
Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus.
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topic |
il-22; oral lichen planus; cutaneous lichen planus; serum |
url |
https://dentjods.sums.ac.ir/article_46238.html |
work_keys_str_mv |
AT maryammardani serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus AT shivatorabiardakani serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus AT ladandastgheib serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus AT nasrinhamidizadeh serumlevelsofil22inpatientswithorallichenplanusandcutaneouslichenplanus |
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