Severe neonatal legionellosis associated with use of home humidifiers – A case report
Neonatal Legionella pneumophila infection is rare and mortality is high. There has been limited success with the use of extracorporeal membrane oxygenation, with reported mortality in infants of 88%. We present the case of a 5 day old infant with neonatal legionellosis who had been exposed to cold m...
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doaj-c5895d7a6d87447987bb236989de9ba72020-12-31T04:44:15ZengElsevierClinical Infection in Practice2590-17022020-10-017100050Severe neonatal legionellosis associated with use of home humidifiers – A case reportRebecca Mitting0Veena Rajagopal1Thalita Grossman2Elizabeth Whittaker3Victoria Chalker4Sandra Lai5Peter Hoffman6Sara Atkin7Sabeena Qureshi8James Hatcher9Imperial College Healthcare NHS Trust, St Mary’s Hospital, Praed Street, London W2 1NY, United Kingdom; Corresponding author at: Paediatric Intensive Care Unit, Imperial College Healthcare NHS Trust, St Mary’s Hospital, Praed Street, London W2 1NY, United Kingdom.Great Ormond Street Hospital for Children, London WC1N 3JH, United KingdomGreat Ormond Street Hospital for Children, London WC1N 3JH, United KingdomImperial College Healthcare NHS Trust, St Mary’s Hospital, Praed Street, London W2 1NY, United Kingdom; Section of Paediatric Infectious Diseases, Imperial College London, School of Medicine, St Mary’s Hospital, Praed Street, London W2 1NY, United KingdomRespiratory and Vaccine Preventable Bacteria Reference Unit, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United KingdomFood Water and Environmental Microbiology Laboratory, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United KingdomHealthcare Associated Infection and Antimicrobial Resistance Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United KingdomNorth West London Health Protection Team, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United KingdomImperial College Healthcare NHS Trust, St Mary’s Hospital, Praed Street, London W2 1NY, United KingdomGreat Ormond Street Hospital for Children, London WC1N 3JH, United KingdomNeonatal Legionella pneumophila infection is rare and mortality is high. There has been limited success with the use of extracorporeal membrane oxygenation, with reported mortality in infants of 88%. We present the case of a 5 day old infant with neonatal legionellosis who had been exposed to cold mist humidifiers in the home, filled from a domestic water supply contaminated with legionella. The infant was treated with veno-arterial extracorporeal membrane oxygenation and survived with subsequently normal neurodevelopmental follow-up. In view of the rapid growth of the worldwide humidifier market, the association between neonatal legionella and use of cold mist humidification may be important. Consideration of legionellosis should be given for any neonate presenting with severe sepsis or respiratory compromise who has been exposed to aerosol generating home humidifiers. In spite of previously reported high mortality in infants, this case demonstrates that excellent outcome is possible with early escalation to VA ECMO.http://www.sciencedirect.com/science/article/pii/S2590170220300376NeonatalLegionella pneumophilliaExtra-corporeal membrane oxygenationHome humidification |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rebecca Mitting Veena Rajagopal Thalita Grossman Elizabeth Whittaker Victoria Chalker Sandra Lai Peter Hoffman Sara Atkin Sabeena Qureshi James Hatcher |
spellingShingle |
Rebecca Mitting Veena Rajagopal Thalita Grossman Elizabeth Whittaker Victoria Chalker Sandra Lai Peter Hoffman Sara Atkin Sabeena Qureshi James Hatcher Severe neonatal legionellosis associated with use of home humidifiers – A case report Clinical Infection in Practice Neonatal Legionella pneumophillia Extra-corporeal membrane oxygenation Home humidification |
author_facet |
Rebecca Mitting Veena Rajagopal Thalita Grossman Elizabeth Whittaker Victoria Chalker Sandra Lai Peter Hoffman Sara Atkin Sabeena Qureshi James Hatcher |
author_sort |
Rebecca Mitting |
title |
Severe neonatal legionellosis associated with use of home humidifiers – A case report |
title_short |
Severe neonatal legionellosis associated with use of home humidifiers – A case report |
title_full |
Severe neonatal legionellosis associated with use of home humidifiers – A case report |
title_fullStr |
Severe neonatal legionellosis associated with use of home humidifiers – A case report |
title_full_unstemmed |
Severe neonatal legionellosis associated with use of home humidifiers – A case report |
title_sort |
severe neonatal legionellosis associated with use of home humidifiers – a case report |
publisher |
Elsevier |
series |
Clinical Infection in Practice |
issn |
2590-1702 |
publishDate |
2020-10-01 |
description |
Neonatal Legionella pneumophila infection is rare and mortality is high. There has been limited success with the use of extracorporeal membrane oxygenation, with reported mortality in infants of 88%. We present the case of a 5 day old infant with neonatal legionellosis who had been exposed to cold mist humidifiers in the home, filled from a domestic water supply contaminated with legionella. The infant was treated with veno-arterial extracorporeal membrane oxygenation and survived with subsequently normal neurodevelopmental follow-up. In view of the rapid growth of the worldwide humidifier market, the association between neonatal legionella and use of cold mist humidification may be important. Consideration of legionellosis should be given for any neonate presenting with severe sepsis or respiratory compromise who has been exposed to aerosol generating home humidifiers. In spite of previously reported high mortality in infants, this case demonstrates that excellent outcome is possible with early escalation to VA ECMO. |
topic |
Neonatal Legionella pneumophillia Extra-corporeal membrane oxygenation Home humidification |
url |
http://www.sciencedirect.com/science/article/pii/S2590170220300376 |
work_keys_str_mv |
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