Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension
Abstract Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjec...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-01-01
|
Series: | Chinese Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13020-020-00417-8 |
id |
doaj-c589ca5dd1884151be296eadede946a7 |
---|---|
record_format |
Article |
spelling |
doaj-c589ca5dd1884151be296eadede946a72021-01-10T12:43:14ZengBMCChinese Medicine1749-85462021-01-0116111110.1186/s13020-020-00417-8Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertensionJun-meng Wang0Ming-xiao Yang1Qiao-feng Wu2Ji Chen3Shu-fang Deng4Lin Chen5Da-neng Wei6Fan-rong Liang7Acupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineSchool of Chinese Medicine, The University of Hong KongAcupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineAcupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineAcupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineAcupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineAcupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineAcupuncture and Moxibustion College, Chengdu University of Traditional Chinese MedicineAbstract Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726https://doi.org/10.1186/s13020-020-00417-8Intestinal floraElectro-acupunctureStage 1 hypertensionDysbiosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun-meng Wang Ming-xiao Yang Qiao-feng Wu Ji Chen Shu-fang Deng Lin Chen Da-neng Wei Fan-rong Liang |
spellingShingle |
Jun-meng Wang Ming-xiao Yang Qiao-feng Wu Ji Chen Shu-fang Deng Lin Chen Da-neng Wei Fan-rong Liang Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension Chinese Medicine Intestinal flora Electro-acupuncture Stage 1 hypertension Dysbiosis |
author_facet |
Jun-meng Wang Ming-xiao Yang Qiao-feng Wu Ji Chen Shu-fang Deng Lin Chen Da-neng Wei Fan-rong Liang |
author_sort |
Jun-meng Wang |
title |
Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension |
title_short |
Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension |
title_full |
Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension |
title_fullStr |
Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension |
title_full_unstemmed |
Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension |
title_sort |
improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension |
publisher |
BMC |
series |
Chinese Medicine |
issn |
1749-8546 |
publishDate |
2021-01-01 |
description |
Abstract Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726 |
topic |
Intestinal flora Electro-acupuncture Stage 1 hypertension Dysbiosis |
url |
https://doi.org/10.1186/s13020-020-00417-8 |
work_keys_str_mv |
AT junmengwang improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT mingxiaoyang improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT qiaofengwu improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT jichen improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT shufangdeng improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT linchen improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT danengwei improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension AT fanrongliang improvementofintestinalfloraaccompanywiththeantihypertensiveeffectofelectroacupunctureonstage1hypertension |
_version_ |
1724342360802852864 |