Polygenic risk and pleiotropy in neurodegenerative diseases

Polygenic risk and pleiotropy in neurodegenerative diseases

In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS) analysis. PRS was designed to assess a...

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Bibliographic Details
Main Authors:	Eftychia Bellou, Joshua Stevenson-Hoare, Valentina Escott-Price
Format:	Article
Language:	English
Published:	Elsevier 2020-08-01
Series:	Neurobiology of Disease
Subjects:	Polygenic risk score Pleiotropy Heritability Neurodegenerative disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S096999612030228X

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