Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment
Breast cancer is the most common invasive tumor in women and the second leading cause of cancer-related death. Nanomedicine raises high expectations for millions of patients as it can provide better, more efficient, and affordable healthcare, and it has the potential to develop novel therapeutics fo...
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doaj-c59099ad60a741249fee2e6fc1bc2e812020-11-25T03:45:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-01216018601810.3390/ijms21176018Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer TreatmentAlberto Juan0Francisco J. Cimas1Iván Bravo2Atanasio Pandiella3Alberto Ocaña4Carlos Alonso-Moreno5Oncología Traslacional, Unidad de Investigación del Complejo Hospitalario Universitario de Albacete, 02008 Albacete, SpainOncología Traslacional, Unidad de Investigación del Complejo Hospitalario Universitario de Albacete, 02008 Albacete, SpainCentro Regional de Investigaciones Biomédicas, Unidad NanoCRIB, 02008 Albacete, SpainCentro de Investigación del Cáncer-CSIC, IBSAL- Salamanca and CIBERONC, 37007 Salamanca, SpainOncología Traslacional, Unidad de Investigación del Complejo Hospitalario Universitario de Albacete, 02008 Albacete, SpainCentro Regional de Investigaciones Biomédicas, Unidad NanoCRIB, 02008 Albacete, SpainBreast cancer is the most common invasive tumor in women and the second leading cause of cancer-related death. Nanomedicine raises high expectations for millions of patients as it can provide better, more efficient, and affordable healthcare, and it has the potential to develop novel therapeutics for the treatment of solid tumors. In this regard, targeted therapies can be encapsulated into nanocarriers, and these nanovehicles are guided to the tumors through conjugation with antibodies—the so-called antibody-conjugated nanoparticles (ACNPs). ACNPs can preserve the chemical structure of drugs, deliver them in a controlled manner, and reduce toxicity. As certain breast cancer subtypes and indications have limited therapeutic options, this field provides hope for the future treatment of patients with difficult to treat breast cancers. In this review, we discuss the application of ACNPs for the treatment of this disease. Given the fact that ACNPs have shown clinical activity in this clinical setting, special emphasis on the role of the nanovehicles and their translation to the clinic is placed on the revision.https://www.mdpi.com/1422-0067/21/17/6018breast cancerantibody drug conjugatesantibody conjugate nanoparticlesnanomedicinestargeted delivery systems |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alberto Juan Francisco J. Cimas Iván Bravo Atanasio Pandiella Alberto Ocaña Carlos Alonso-Moreno |
spellingShingle |
Alberto Juan Francisco J. Cimas Iván Bravo Atanasio Pandiella Alberto Ocaña Carlos Alonso-Moreno Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment International Journal of Molecular Sciences breast cancer antibody drug conjugates antibody conjugate nanoparticles nanomedicines targeted delivery systems |
author_facet |
Alberto Juan Francisco J. Cimas Iván Bravo Atanasio Pandiella Alberto Ocaña Carlos Alonso-Moreno |
author_sort |
Alberto Juan |
title |
Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment |
title_short |
Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment |
title_full |
Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment |
title_fullStr |
Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment |
title_full_unstemmed |
Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment |
title_sort |
antibody conjugation of nanoparticles as therapeutics for breast cancer treatment |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-08-01 |
description |
Breast cancer is the most common invasive tumor in women and the second leading cause of cancer-related death. Nanomedicine raises high expectations for millions of patients as it can provide better, more efficient, and affordable healthcare, and it has the potential to develop novel therapeutics for the treatment of solid tumors. In this regard, targeted therapies can be encapsulated into nanocarriers, and these nanovehicles are guided to the tumors through conjugation with antibodies—the so-called antibody-conjugated nanoparticles (ACNPs). ACNPs can preserve the chemical structure of drugs, deliver them in a controlled manner, and reduce toxicity. As certain breast cancer subtypes and indications have limited therapeutic options, this field provides hope for the future treatment of patients with difficult to treat breast cancers. In this review, we discuss the application of ACNPs for the treatment of this disease. Given the fact that ACNPs have shown clinical activity in this clinical setting, special emphasis on the role of the nanovehicles and their translation to the clinic is placed on the revision. |
topic |
breast cancer antibody drug conjugates antibody conjugate nanoparticles nanomedicines targeted delivery systems |
url |
https://www.mdpi.com/1422-0067/21/17/6018 |
work_keys_str_mv |
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1724510240438747136 |