Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death
ObjectiveIt has been suggested that the mechanism behind cardiac troponin elevation after strenuous exercise is passage through a cell membrane with changed permeability rather than myocardial cell death. We hypothesised that an increase of cardiac specific myosin heavy chain-alpha (MHC-α; 224 kDa c...
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doaj-c595630db5414ce3816d9fd5b79e64302021-06-11T10:00:30ZengBMJ Publishing GroupBMJ Open Sport & Exercise Medicine2055-76472019-10-015110.1136/bmjsem-2018-000486Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell deathTom Danielsson0Hendrik Schreyer1Hanna Woksepp2Therese Johansson3Patrick Bergman4Alf Månsson5Jörg Carlsson61 Department of Sport Sciences, Linnæus University, Kalmar, Sweden2 Department of Internal Medicine, Section of Cardiology, Kalmar County Hospital, Kalmar, Sweden3 Department of Clinical Microbiology and Research Section Development and Public Health Unit, Kalmar County Hospital, Kalmar, Sweden2 Department of Internal Medicine, Section of Cardiology, Kalmar County Hospital, Kalmar, Sweden1 Department of Sport Sciences, Linnæus University, Kalmar, Sweden4 Department of Chemistry and Biomedical Sciences, Linnæus University, Kalmar, Sweden2 Department of Internal Medicine, Section of Cardiology, Kalmar County Hospital, Kalmar, Sweden ObjectiveIt has been suggested that the mechanism behind cardiac troponin elevation after strenuous exercise is passage through a cell membrane with changed permeability rather than myocardial cell death. We hypothesised that an increase of cardiac specific myosin heavy chain-alpha (MHC-α; 224 kDa compared with cardiac troponin T’s (cTnT) 37 kDa) could hardly be explained by passage through a cell membrane.MethodsBlood samples were collected from 56 athletes (15 female, age 42.5±9.7, range 24–70 years) before, directly after and on days 1–8 after an Ironman. Biomarkers (C reactive protein (CRP), cTnT, creatine kinase (CK), MHC-α, myoglobin (MG), creatinine (C) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured.ResultsThe course of MHC-α concentration (µg/L) was 1.33±0.53 (before), 2.57±0.78 (directly after), 1.51±0.53 (day 1), 2.74±0.55 (day 4) and 1.83±0.76 (day 6). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ± 80 ng/L (12–440; reference<15), NT-proBNP 776±684 ng/L (92–4700; ref.<300), CK 68±55 µkat/L (5–280; ref.<1.9), MG 2088±2350 µg/L (130–17 000; ref.<72) and creatinine 100±20 µmol/L (74–161; ref.<100), CRP 49±23 mg/L (15–119; ref.<5).ConclusionMHC-α exhibited a two-peaked increase which could represent a first release from the cytosolic pool and later from cell necrosis. This is the first investigation of MHC-α plasma concentration after exercise.https://bmjopensem.bmj.com/content/5/1/e000486.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tom Danielsson Hendrik Schreyer Hanna Woksepp Therese Johansson Patrick Bergman Alf Månsson Jörg Carlsson |
spellingShingle |
Tom Danielsson Hendrik Schreyer Hanna Woksepp Therese Johansson Patrick Bergman Alf Månsson Jörg Carlsson Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death BMJ Open Sport & Exercise Medicine |
author_facet |
Tom Danielsson Hendrik Schreyer Hanna Woksepp Therese Johansson Patrick Bergman Alf Månsson Jörg Carlsson |
author_sort |
Tom Danielsson |
title |
Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death |
title_short |
Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death |
title_full |
Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death |
title_fullStr |
Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death |
title_full_unstemmed |
Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death |
title_sort |
two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death |
publisher |
BMJ Publishing Group |
series |
BMJ Open Sport & Exercise Medicine |
issn |
2055-7647 |
publishDate |
2019-10-01 |
description |
ObjectiveIt has been suggested that the mechanism behind cardiac troponin elevation after strenuous exercise is passage through a cell membrane with changed permeability rather than myocardial cell death. We hypothesised that an increase of cardiac specific myosin heavy chain-alpha (MHC-α; 224 kDa compared with cardiac troponin T’s (cTnT) 37 kDa) could hardly be explained by passage through a cell membrane.MethodsBlood samples were collected from 56 athletes (15 female, age 42.5±9.7, range 24–70 years) before, directly after and on days 1–8 after an Ironman. Biomarkers (C reactive protein (CRP), cTnT, creatine kinase (CK), MHC-α, myoglobin (MG), creatinine (C) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured.ResultsThe course of MHC-α concentration (µg/L) was 1.33±0.53 (before), 2.57±0.78 (directly after), 1.51±0.53 (day 1), 2.74±0.55 (day 4) and 1.83±0.76 (day 6). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ± 80 ng/L (12–440; reference<15), NT-proBNP 776±684 ng/L (92–4700; ref.<300), CK 68±55 µkat/L (5–280; ref.<1.9), MG 2088±2350 µg/L (130–17 000; ref.<72) and creatinine 100±20 µmol/L (74–161; ref.<100), CRP 49±23 mg/L (15–119; ref.<5).ConclusionMHC-α exhibited a two-peaked increase which could represent a first release from the cytosolic pool and later from cell necrosis. This is the first investigation of MHC-α plasma concentration after exercise. |
url |
https://bmjopensem.bmj.com/content/5/1/e000486.full |
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