Primary Localized Amyloidosis of the Bladder Mimicking Neoplasia

• Main Authors: Sümeyye Ekmekçi, Ülkü Küçük, Ebru Çakır, Emel Ebru Pala, Samir Abdullazade, Özgür Çakmak
• Format: Article
• Language: English
• Published: Galenos Yayinevi 2018-06-01
• Series: Journal of Urological Surgery
• Subjects: Primary; Amyloidosis; Bladder
• Online Access: http://jurolsurgery.org/archives/archive-detail/article-preview/primary-localized-amyloidosis-of-the-bladder-mimic/18507

A 63-year-old woman was admitted to our hospital with macroscopic hematuria in 2013. On computed tomography, the bladder wall thickness was 2 cm, suspicious for malignancy. Cystoscopy showed irregularity in the posterolateral side of the bladder. Transurethral resection was performed. Histopathological examination revealed a dense homogeneous eosinophilic material in the lamina propria which showed positive orange-red staining with apple-green birefringence under polarized light. There were no signs of systemic amyloidosis at the time of diagnosis and during the 36 months of follow-up. Differential diagnosis of amyloidosis in the bladder includes urothelial carcinoma due to its appearance on imaging and cystoscopy. Histopathological evaluation is a requirement for accurate diagnosis.