Application of homozygosity haplotype analysis to genetic mapping with high-density SNP genotype data.
BACKGROUND: In families segregating a monogenic genetic disorder with a single disease gene introduction, patients share a mutation-carrying chromosomal interval with identity-by-descent (IBD). Such a shared chromosomal interval or haplotype, surrounding the actual pathogenic mutation, is typically...
Main Authors: | Haiyan Jiang, Andrew Orr, Duane L Guernsey, Johane Robitaille, Géraldine Asselin, Mark E Samuels, Marie-Pierre Dubé |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2670504?pdf=render |
Similar Items
-
KinSNP software for homozygosity mapping of disease genes using SNP microarrays
by: Amir El-Ad, et al.
Published: (2010-08-01) -
Homozygosity mapping on homozygosity haplotype analysis to detect recessive disease-causing genes from a small number of unrelated, outbred patients.
by: Koichi Hagiwara, et al.
Published: (2011-01-01) -
The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome
by: Molly B. Sheridan, et al.
Published: (2015-01-01) -
SNP haplotype mapping in a small ALS family.
by: Katherine A Dick Krueger, et al.
Published: (2009-05-01) -
Minimum Conflict Individual Haplotyping from SNP Fragments and Related Genotype
by: Xiang-Sun Zhang, et al.
Published: (2006-01-01)