Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extracellular ATP Accumulation and Facilitates P2X7 Receptor Activation

Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extracellular ATP Accumulation and Facilitates P2X7 Receptor Activation

Toll-like receptors (TLRs) trigger innate immune responses through their recognition of conserved molecular ligands of either endogenous or microbial origin. Although activation, function, and signaling pathways of TLRs were already well-studied, their precise function in specific cell types, especi...

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Bibliographic Details
Main Authors: Ronglan Zhao, Jinjuan Qiao, Xumei Zhang, Yansong Zhao, Xiangying Meng, Deming Sun, Xiaoxiang Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
ATP
CD39
internalization
P2X7R
toll-like receptor ligands
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02524/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02524/full

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