Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients
Non-small cell lung cancer (NSCLC) is the main reason of cancer linked mortality and around 80% of cases diagnosed in advanced stage. Therefore current study designed to evaluate the deregulation of miRNA-194 and miRNA-192 in different body fluid of Non small cell lung cancer participants. Present s...
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doaj-c5a8ec4cf36d4505ba6601ebab4091c12021-03-05T04:27:32ZengElsevierSaudi Journal of Biological Sciences1319-562X2021-03-0128315611568Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patientsTongfei Wang0Wei Li1Haitao Li2Weina Li3Department of Oncology, Xi’an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi 710018, ChinaDepartment of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710038, ChinaDepartment of Oncology, Xi’an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi 710018, ChinaBiotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an, Shaanxi 710032, China; Corresponding author.Non-small cell lung cancer (NSCLC) is the main reason of cancer linked mortality and around 80% of cases diagnosed in advanced stage. Therefore current study designed to evaluate the deregulation of miRNA-194 and miRNA-192 in different body fluid of Non small cell lung cancer participants. Present study recruited newly diagnosed histopathologically confirmed. It was observed that the 40% NSCLC participants showed elevated miR-194 expression and 60% NSCLC participants showed reduced miR-194 expression in serum sample while in Bronchial wash, only 20% NSCLC participants showed elevated miR-194 expression while 80% showed reduced miR-194 expression (p = 0.003). It was found that the 54% NSCLC participants showed elevated miR-192 expression and 55% NSCLC participants showed reduced miR-192 expression in serum sample while In Bronchial wash sample, only 25% NSCLC participants showed high miR-192 expression while 75% showed low miR-192 expression (P = 0.0004). Expression of miR-194 was significantly associated with TNM stages (p < 0.0001, p < 0.0001), distant organ metastases (p < 0.0001, p < 0.0001), pathological grade (p = 0.0009, p = 0.0005) among serum sample and bronchial wash sample. Same observation was found with expression of miR-192 and it was significantly associated with TNM stages (p < 0.0001, p < 0.0001), distant organ metastases (p < 0.0001, p < 0.0001), pathological grade (p = 0.006, p = 0.001) among serum sample and bronchial wash sample. It was observed that the NSCLC participants who had high serum based miR-194 expression showed 22 months of overall median survival while low expression of serum based miR-194 expression showed 18 months of overall median survival. Present study suggests that decreased expression of miR-194 and miR-192 was significantly associated with different clinical features of NSCLC cases. However, significantly higher number of NSCLC cases showed low expression of miR-194 and miR-192 in bronchial lavage sample. Decreased poor overall survival was found to be associated with bronchial wash sample with respect to low miR-194 and miR-192 expression while NSCLC participants showed better overall survival with high miR-194 and miR-192 expression. This suggested decreased expression of miR-192 and miR-194 expression could be the potential prognostic marker among NSCLC participants.http://www.sciencedirect.com/science/article/pii/S1319562X21000139Non-small cell lung cancermiR-194miR-192Histopathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tongfei Wang Wei Li Haitao Li Weina Li |
spellingShingle |
Tongfei Wang Wei Li Haitao Li Weina Li Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients Saudi Journal of Biological Sciences Non-small cell lung cancer miR-194 miR-192 Histopathology |
author_facet |
Tongfei Wang Wei Li Haitao Li Weina Li |
author_sort |
Tongfei Wang |
title |
Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients |
title_short |
Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients |
title_full |
Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients |
title_fullStr |
Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients |
title_full_unstemmed |
Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients |
title_sort |
dysregulation of exosomal mir-192 and mir-194 expression in lung adenocarcinoma patients |
publisher |
Elsevier |
series |
Saudi Journal of Biological Sciences |
issn |
1319-562X |
publishDate |
2021-03-01 |
description |
Non-small cell lung cancer (NSCLC) is the main reason of cancer linked mortality and around 80% of cases diagnosed in advanced stage. Therefore current study designed to evaluate the deregulation of miRNA-194 and miRNA-192 in different body fluid of Non small cell lung cancer participants. Present study recruited newly diagnosed histopathologically confirmed. It was observed that the 40% NSCLC participants showed elevated miR-194 expression and 60% NSCLC participants showed reduced miR-194 expression in serum sample while in Bronchial wash, only 20% NSCLC participants showed elevated miR-194 expression while 80% showed reduced miR-194 expression (p = 0.003). It was found that the 54% NSCLC participants showed elevated miR-192 expression and 55% NSCLC participants showed reduced miR-192 expression in serum sample while In Bronchial wash sample, only 25% NSCLC participants showed high miR-192 expression while 75% showed low miR-192 expression (P = 0.0004). Expression of miR-194 was significantly associated with TNM stages (p < 0.0001, p < 0.0001), distant organ metastases (p < 0.0001, p < 0.0001), pathological grade (p = 0.0009, p = 0.0005) among serum sample and bronchial wash sample. Same observation was found with expression of miR-192 and it was significantly associated with TNM stages (p < 0.0001, p < 0.0001), distant organ metastases (p < 0.0001, p < 0.0001), pathological grade (p = 0.006, p = 0.001) among serum sample and bronchial wash sample. It was observed that the NSCLC participants who had high serum based miR-194 expression showed 22 months of overall median survival while low expression of serum based miR-194 expression showed 18 months of overall median survival. Present study suggests that decreased expression of miR-194 and miR-192 was significantly associated with different clinical features of NSCLC cases. However, significantly higher number of NSCLC cases showed low expression of miR-194 and miR-192 in bronchial lavage sample. Decreased poor overall survival was found to be associated with bronchial wash sample with respect to low miR-194 and miR-192 expression while NSCLC participants showed better overall survival with high miR-194 and miR-192 expression. This suggested decreased expression of miR-192 and miR-194 expression could be the potential prognostic marker among NSCLC participants. |
topic |
Non-small cell lung cancer miR-194 miR-192 Histopathology |
url |
http://www.sciencedirect.com/science/article/pii/S1319562X21000139 |
work_keys_str_mv |
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