Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia
Abstract Background Multidrug-resistant tuberculosis (MDR-TB) is resistant to the two main first-line anti-tuberculosis drugs: rifampicin and isoniazid. It is a major threat to public health worldwide. The objective of this study was to assess the potential risk factors for multidrug-resistant tuber...
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doaj-c5b22ac506ce4c8c91fa53fe07adb8612020-11-24T21:24:20ZengBMCBMC Public Health1471-24582018-04-011811610.1186/s12889-018-5371-3Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, EthiopiaFanta Desissa0Tilaye Workineh1Takele Beyene2Department of Microbiology, Immunology and Veterinary Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa UniversityAdama Hospital Medical CollegeDepartment of Biomedical Science, College of Veterinary Medicine and Agriculture, Addis Ababa UniversityAbstract Background Multidrug-resistant tuberculosis (MDR-TB) is resistant to the two main first-line anti-tuberculosis drugs: rifampicin and isoniazid. It is a major threat to public health worldwide. The objective of this study was to assess the potential risk factors for multidrug-resistant tuberculosis among patients undergoing MDR-TB treatment at two community hospitals in Ethiopia. Methods A case-control study design was conducted from February 1, 2016, to April 29, 2016. TB-positive patients with MDR-TB and non-MDR-TB were considered as cases and controls, respectively. A total of 219 study participants were included in the study. An interviewer-administered structured questionnaire was used to collect primary data from the patients, and a checklist was used to collect data from the clinical records. Bivariate and multivariate logistic regression analyses were used to assess the potential risk factors for the occurrence of MDR-TB. Results The odds of developing MDR-TB were higher in patients previously treated with anti-TB drugs (odds ratio [OR] = 6.1, 95%CI: 2.92–12.62, P < 0.001), those with a history of contact with known TB patients (OR = 2.1, 95%CI: 1.04–4.43, P < 0.001), those living in a rural setting (OR = 5.6, 95%CI: 2.14–14.46, P = 0.001), those with a history of alcohol consumption (OR = 4.3, 95%CI: 2.29–10.49, P < 0.001) and those without a job (OR = 2.4, 95%CI: 1.06–5.42, P = 0.001). Conclusions The study revealed that contact with known TB patients, previous TB treatment, residence area, lack of a job, and alcohol consumption were potential risk factors for the occurrence of MDR-TB. Enhancing public health education, intensifying directly observed therapy programmes for all TB patients and designing control strategies are recommended.http://link.springer.com/article/10.1186/s12889-018-5371-3MDR-TBTBRisk factorsAnti-TB drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fanta Desissa Tilaye Workineh Takele Beyene |
spellingShingle |
Fanta Desissa Tilaye Workineh Takele Beyene Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia BMC Public Health MDR-TB TB Risk factors Anti-TB drugs |
author_facet |
Fanta Desissa Tilaye Workineh Takele Beyene |
author_sort |
Fanta Desissa |
title |
Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia |
title_short |
Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia |
title_full |
Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia |
title_fullStr |
Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia |
title_full_unstemmed |
Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia |
title_sort |
risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in east shoa, ethiopia |
publisher |
BMC |
series |
BMC Public Health |
issn |
1471-2458 |
publishDate |
2018-04-01 |
description |
Abstract Background Multidrug-resistant tuberculosis (MDR-TB) is resistant to the two main first-line anti-tuberculosis drugs: rifampicin and isoniazid. It is a major threat to public health worldwide. The objective of this study was to assess the potential risk factors for multidrug-resistant tuberculosis among patients undergoing MDR-TB treatment at two community hospitals in Ethiopia. Methods A case-control study design was conducted from February 1, 2016, to April 29, 2016. TB-positive patients with MDR-TB and non-MDR-TB were considered as cases and controls, respectively. A total of 219 study participants were included in the study. An interviewer-administered structured questionnaire was used to collect primary data from the patients, and a checklist was used to collect data from the clinical records. Bivariate and multivariate logistic regression analyses were used to assess the potential risk factors for the occurrence of MDR-TB. Results The odds of developing MDR-TB were higher in patients previously treated with anti-TB drugs (odds ratio [OR] = 6.1, 95%CI: 2.92–12.62, P < 0.001), those with a history of contact with known TB patients (OR = 2.1, 95%CI: 1.04–4.43, P < 0.001), those living in a rural setting (OR = 5.6, 95%CI: 2.14–14.46, P = 0.001), those with a history of alcohol consumption (OR = 4.3, 95%CI: 2.29–10.49, P < 0.001) and those without a job (OR = 2.4, 95%CI: 1.06–5.42, P = 0.001). Conclusions The study revealed that contact with known TB patients, previous TB treatment, residence area, lack of a job, and alcohol consumption were potential risk factors for the occurrence of MDR-TB. Enhancing public health education, intensifying directly observed therapy programmes for all TB patients and designing control strategies are recommended. |
topic |
MDR-TB TB Risk factors Anti-TB drugs |
url |
http://link.springer.com/article/10.1186/s12889-018-5371-3 |
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