Ammonia as a neuro- and hepatotoxin: clinical aspects
Ammonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as well as hepatotoxic effects. A recent study a...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2015-12-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/340 |
| id |
doaj-c5b266b957bb420aa870f9d49d3b0d9a |
|---|---|
| record_format |
Article |
| spelling |
doaj-c5b266b957bb420aa870f9d49d3b0d9a2021-07-28T13:29:21ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902015-12-01013808510.21518/2079-701X-2015-13-80-85340Ammonia as a neuro- and hepatotoxin: clinical aspectsA. O. Bueverov0First Moscow State Medical University named after I.M. SechenovAmmonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as well as hepatotoxic effects. A recent study allowed to register presence of hyperammonemia in patients with initial liver changes leading to latent cognitive dysfunction, which manifests itself in impaired reaction in stressful situations. Drug therapy of PE is primarily aimed at prevention and acceleration of metabolism of ammonia. Administration of ornithine metabolites reduces hyperammonemia, improves cognitive function and reduces enzyme activity, including in patients at pre-cirrhotic stage.https://www.med-sovet.pro/jour/article/view/340аммиакпеченочная энцефалопатиялечениеорнитинammoniahepatic encephalopathytreatmentornithine |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
A. O. Bueverov |
| spellingShingle |
A. O. Bueverov Ammonia as a neuro- and hepatotoxin: clinical aspects Медицинский совет аммиак печеночная энцефалопатия лечение орнитин ammonia hepatic encephalopathy treatment ornithine |
| author_facet |
A. O. Bueverov |
| author_sort |
A. O. Bueverov |
| title |
Ammonia as a neuro- and hepatotoxin: clinical aspects |
| title_short |
Ammonia as a neuro- and hepatotoxin: clinical aspects |
| title_full |
Ammonia as a neuro- and hepatotoxin: clinical aspects |
| title_fullStr |
Ammonia as a neuro- and hepatotoxin: clinical aspects |
| title_full_unstemmed |
Ammonia as a neuro- and hepatotoxin: clinical aspects |
| title_sort |
ammonia as a neuro- and hepatotoxin: clinical aspects |
| publisher |
Remedium Group LLC |
| series |
Медицинский совет |
| issn |
2079-701X 2658-5790 |
| publishDate |
2015-12-01 |
| description |
Ammonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as well as hepatotoxic effects. A recent study allowed to register presence of hyperammonemia in patients with initial liver changes leading to latent cognitive dysfunction, which manifests itself in impaired reaction in stressful situations. Drug therapy of PE is primarily aimed at prevention and acceleration of metabolism of ammonia. Administration of ornithine metabolites reduces hyperammonemia, improves cognitive function and reduces enzyme activity, including in patients at pre-cirrhotic stage. |
| topic |
аммиак печеночная энцефалопатия лечение орнитин ammonia hepatic encephalopathy treatment ornithine |
| url |
https://www.med-sovet.pro/jour/article/view/340 |
| work_keys_str_mv |
AT aobueverov ammoniaasaneuroandhepatotoxinclinicalaspects |
| _version_ |
1721274530972827648 |