Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
It seems that during SARS-CoV-2 infection, total cholesterol, LDL-C, and HDL-C values decrease and lipids could play a fundamental role in viral replication. Moreover, it has been shown that SARS-CoV-2 infection could influence thyroid function. We performed a retrospective analysis of 118 hospitali...
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doaj-c5ca86ce815c4f0db9bb7aa1f3479a9b2021-08-26T13:59:23ZengMDPI AGLife2075-17292021-08-011186086010.3390/life11080860Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 PatientsDamiano D’Ardes0Ilaria Rossi1Benedetta Bucciarelli2Marco Allegra3Francesco Bianco4Bruna Sinjari5Michele Marchioni6Marta Di Nicola7Francesca Santilli8Maria Teresa Guagnano9Francesco Cipollone10Marco Bucci11“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, ItalyPediatric Cardiology and Adult Congenital Heart Disease, Azienda Ospedaliero-Universitaria “Ospedali Riuniti” of Ancona, 60126 Ancona, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, “G. d’Annunzio” University, Chieti-Pescara, 66100 Chieti, ItalyLaboratory of Biostatistics, Department of “Medical, Oral and Biotechnological Sciences”, “G. d’Annunzio” University, Chieti-Pescara, 66100 Chieti, ItalyLaboratory of Biostatistics, Department of “Medical, Oral and Biotechnological Sciences”, “G. d’Annunzio” University, Chieti-Pescara, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, Italy“Clinica Medica” Institute, Department of “Medicine and Science of Aging”, “G. d’Annunzio” University, 66100 Chieti, ItalyIt seems that during SARS-CoV-2 infection, total cholesterol, LDL-C, and HDL-C values decrease and lipids could play a fundamental role in viral replication. Moreover, it has been shown that SARS-CoV-2 infection could influence thyroid function. We performed a retrospective analysis of 118 hospitalized patients with COVID-19, comparing pre-infection lipid profile (53 patients) and thyroid-stimulating hormone (TSH) values (45 patients) to those measured on admission. Our aim was to evaluate whether SARS-CoV-2 infection could be involved in thyroid and lipid profile alterations and study possible correlations with disease severity and clinical outcome. Median baseline values at the admission time were: total cholesterol at 136.89 ± 42.73 mg/dL, LDL-C 81.53 ± 30.35 mg/dL, and HDL-C 32.36 ± 15.13 mg/dL; and triglycerides at 115.00 ± 40.45 mg/dL, non-HDL-C 104.53 ± 32.63 md/dL, and TSH 1.15 ± 1.08 μUI/mL. Median values of pre-infection total cholesterol, HDL-C, and TSH were significantly higher than those measured at the admission time (<i>p</i> value < 0.05). The C-reactive protein (CRP) negatively correlated with LDL-C (<i>p</i> = 0.013) and HDL-C (<i>p</i> = 0.05). Our data underline a possible impact of SARS-CoV-2 infection on thyroid function. Moreover it suggests a possible relation between COVID-19 and the lipid profile with a negative correlation between CRP, LDL-C, and HDL-C values, proposing the hypothesis that lipid lowering could follow the rising of the COVID-19 inflammatory state.https://www.mdpi.com/2075-1729/11/8/860COVID-19SARS-CoV-2lipidscholesterolthyroid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Damiano D’Ardes Ilaria Rossi Benedetta Bucciarelli Marco Allegra Francesco Bianco Bruna Sinjari Michele Marchioni Marta Di Nicola Francesca Santilli Maria Teresa Guagnano Francesco Cipollone Marco Bucci |
spellingShingle |
Damiano D’Ardes Ilaria Rossi Benedetta Bucciarelli Marco Allegra Francesco Bianco Bruna Sinjari Michele Marchioni Marta Di Nicola Francesca Santilli Maria Teresa Guagnano Francesco Cipollone Marco Bucci Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients Life COVID-19 SARS-CoV-2 lipids cholesterol thyroid |
author_facet |
Damiano D’Ardes Ilaria Rossi Benedetta Bucciarelli Marco Allegra Francesco Bianco Bruna Sinjari Michele Marchioni Marta Di Nicola Francesca Santilli Maria Teresa Guagnano Francesco Cipollone Marco Bucci |
author_sort |
Damiano D’Ardes |
title |
Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients |
title_short |
Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients |
title_full |
Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients |
title_fullStr |
Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients |
title_full_unstemmed |
Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients |
title_sort |
metabolic changes in sars-cov-2 infection: clinical data and molecular hypothesis to explain alterations of lipid profile and thyroid function observed in covid-19 patients |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2021-08-01 |
description |
It seems that during SARS-CoV-2 infection, total cholesterol, LDL-C, and HDL-C values decrease and lipids could play a fundamental role in viral replication. Moreover, it has been shown that SARS-CoV-2 infection could influence thyroid function. We performed a retrospective analysis of 118 hospitalized patients with COVID-19, comparing pre-infection lipid profile (53 patients) and thyroid-stimulating hormone (TSH) values (45 patients) to those measured on admission. Our aim was to evaluate whether SARS-CoV-2 infection could be involved in thyroid and lipid profile alterations and study possible correlations with disease severity and clinical outcome. Median baseline values at the admission time were: total cholesterol at 136.89 ± 42.73 mg/dL, LDL-C 81.53 ± 30.35 mg/dL, and HDL-C 32.36 ± 15.13 mg/dL; and triglycerides at 115.00 ± 40.45 mg/dL, non-HDL-C 104.53 ± 32.63 md/dL, and TSH 1.15 ± 1.08 μUI/mL. Median values of pre-infection total cholesterol, HDL-C, and TSH were significantly higher than those measured at the admission time (<i>p</i> value < 0.05). The C-reactive protein (CRP) negatively correlated with LDL-C (<i>p</i> = 0.013) and HDL-C (<i>p</i> = 0.05). Our data underline a possible impact of SARS-CoV-2 infection on thyroid function. Moreover it suggests a possible relation between COVID-19 and the lipid profile with a negative correlation between CRP, LDL-C, and HDL-C values, proposing the hypothesis that lipid lowering could follow the rising of the COVID-19 inflammatory state. |
topic |
COVID-19 SARS-CoV-2 lipids cholesterol thyroid |
url |
https://www.mdpi.com/2075-1729/11/8/860 |
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