Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report
Meningiomas are usually benign but can extend to their surroundings, infiltrating skeletal and brain structures. Skull invasion by meningiomas could be associated with adverse outcomes, including progression and recurrence. The molecular mechanisms regulating the invasive potential of these tumors a...
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doaj-c5cc74de09814cf8be0ed7d364f482c02021-09-15T04:22:01ZengElsevierInterdisciplinary Neurosurgery2214-75192022-03-0127101374Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case reportParménides Guadarrama-Ortíz0Ingrid Montes de Oca-Vargas1José Alberto Choreño-Parra2Cecilia Gallegos-Garza3Carlos Sánchez-Garibay4André Garibay-Gracián5Citlaltepetl Salinas-Lara6Gerardo Guinto7Department of Neurosurgery, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, Mexico; Corresponding author at: Department of Neurosurgery, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Tlaxcala 84, Roma Sur, 06760 Mexico City, Mexico.Department of Neurosurgery, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, Mexico; Programa de Servicio Social en Investigación, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, Mexico; Facultad de Estudios Superiores (FES) Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla de Baz, MexicoDepartment of Neurosurgery, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, MexicoDepartment of Pathology, Hospital Ángeles del Pedregal, Mexico City, MexicoDepartment of Neuropathology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoDepartment of Neurosurgery, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, Mexico; Programa de Servicio Social en Investigación, Centro Especializado en Neurocirugía y Neurociencias México (CENNM), Mexico City, Mexico; Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City, MexicoDepartment of Neuropathology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoDepartment of Neurosurgery, Centro Neurológico ABC, Mexico City, MexicoMeningiomas are usually benign but can extend to their surroundings, infiltrating skeletal and brain structures. Skull invasion by meningiomas could be associated with adverse outcomes, including progression and recurrence. The molecular mechanisms regulating the invasive potential of these tumors are not well characterized. Here, we describe the clinical, imaging, and neuropsychological characteristics of a patient with a convexity fibrous meningioma invading the skull. Furthermore, we analyzed the tumoral expression of some molecular factors potentially implicated in bone invasion using immunohistochemistry. Our analysis reveals high expression of matrix metalloproteinase 1 (MMP-1), MMP-2, MMP-9, and interleukin 6 (IL-6) in the resected meningioma. Importantly, little brain expression of these factors was detected in public human tissue gene expression databases, nor a meningioma without hyperostosis that served as a control. Our study suggests a possible role for IL-6 and matrix-metalloproteinases in bone invasion by meningiomas that must be validated in larger cohorts.http://www.sciencedirect.com/science/article/pii/S2214751921002863Convexity meningiomasBone invasionHyperostosisMatrix metalloproteinasesIL-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parménides Guadarrama-Ortíz Ingrid Montes de Oca-Vargas José Alberto Choreño-Parra Cecilia Gallegos-Garza Carlos Sánchez-Garibay André Garibay-Gracián Citlaltepetl Salinas-Lara Gerardo Guinto |
spellingShingle |
Parménides Guadarrama-Ortíz Ingrid Montes de Oca-Vargas José Alberto Choreño-Parra Cecilia Gallegos-Garza Carlos Sánchez-Garibay André Garibay-Gracián Citlaltepetl Salinas-Lara Gerardo Guinto Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report Interdisciplinary Neurosurgery Convexity meningiomas Bone invasion Hyperostosis Matrix metalloproteinases IL-6 |
author_facet |
Parménides Guadarrama-Ortíz Ingrid Montes de Oca-Vargas José Alberto Choreño-Parra Cecilia Gallegos-Garza Carlos Sánchez-Garibay André Garibay-Gracián Citlaltepetl Salinas-Lara Gerardo Guinto |
author_sort |
Parménides Guadarrama-Ortíz |
title |
Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report |
title_short |
Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report |
title_full |
Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report |
title_fullStr |
Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report |
title_full_unstemmed |
Expression of IL-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: Case report |
title_sort |
expression of il-6 and matrix metalloproteinases in a convexity meningiomas with hyperostosis: case report |
publisher |
Elsevier |
series |
Interdisciplinary Neurosurgery |
issn |
2214-7519 |
publishDate |
2022-03-01 |
description |
Meningiomas are usually benign but can extend to their surroundings, infiltrating skeletal and brain structures. Skull invasion by meningiomas could be associated with adverse outcomes, including progression and recurrence. The molecular mechanisms regulating the invasive potential of these tumors are not well characterized. Here, we describe the clinical, imaging, and neuropsychological characteristics of a patient with a convexity fibrous meningioma invading the skull. Furthermore, we analyzed the tumoral expression of some molecular factors potentially implicated in bone invasion using immunohistochemistry. Our analysis reveals high expression of matrix metalloproteinase 1 (MMP-1), MMP-2, MMP-9, and interleukin 6 (IL-6) in the resected meningioma. Importantly, little brain expression of these factors was detected in public human tissue gene expression databases, nor a meningioma without hyperostosis that served as a control. Our study suggests a possible role for IL-6 and matrix-metalloproteinases in bone invasion by meningiomas that must be validated in larger cohorts. |
topic |
Convexity meningiomas Bone invasion Hyperostosis Matrix metalloproteinases IL-6 |
url |
http://www.sciencedirect.com/science/article/pii/S2214751921002863 |
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