Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters
Objectives: As the member of the Fox family of transcription factors, Forkhead box M1 (FoxM1) is known to be critical in pathogenesis and development of many solid tumors. However, the clinical value and expression pattern in non-small cell lung cancer (NSCLC) is still poorly understood. Methods: In...
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doaj-c5d54a7f684f4e7e838e07fa74d5dd362021-09-05T20:42:21ZengDe GruyterOpen Life Sciences2391-54122016-01-0111122022410.1515/biol-2016-0030biol-2016-0030Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parametersWang Chongwei0Wang Chongbang1Duan Shufang2Department of Pathology, Hangzhou Third Hospital, Hangzhou, 310009 China65711 Hospital, Chinese People’s Liberation Army, DaLian, 116500 ChinaDepartment of Endocrine, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005 ChinaObjectives: As the member of the Fox family of transcription factors, Forkhead box M1 (FoxM1) is known to be critical in pathogenesis and development of many solid tumors. However, the clinical value and expression pattern in non-small cell lung cancer (NSCLC) is still poorly understood. Methods: In this study, real-time PCR was mainly applied to examine the gene expression levels of FoxM1 in 120 pairs of clinical NSCLC tissues, which were classified into different groups according to smoking status, lymph node metastasis, and tumor grade. By utilizing the online Kaplan-Meier plotter, overall survival analysis was performed to study the correlation between FoxM1 expression and prognosis of lung cancer (LC) patients. Afterwards, the correlation of FoxM1 gene expression and the clinical pathological parameters was examined by κ2 test in these 120 NSCLC patients. Results: FoxM1 was found to be aberrantly upregulated in NSCLC patients, and its overexpression was correlated to groups designated as smokers, cases of positive lymph node metastasis and cases of advanced tumor grades. Online survival analysis showed that high expression of FoxM1 predicted shorter overall survival of NSCLC patients. Additionally, FoxM1 upregulation was statistically correlated with positive smoking history, lymph node metastasis and higher tumor grades. Conclusion: FoxM1 is overexpressed in cancerous tissues and is associated with the poor prognosis of NSCLC patients. Our results provide insights into the utility of FoxM1 as an important biomarker and prognostic factor for NSCLC.https://doi.org/10.1515/biol-2016-0030foxm1upregulationnsclcprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wang Chongwei Wang Chongbang Duan Shufang |
spellingShingle |
Wang Chongwei Wang Chongbang Duan Shufang Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters Open Life Sciences foxm1 upregulation nsclc prognosis |
author_facet |
Wang Chongwei Wang Chongbang Duan Shufang |
author_sort |
Wang Chongwei |
title |
Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters |
title_short |
Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters |
title_full |
Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters |
title_fullStr |
Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters |
title_full_unstemmed |
Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters |
title_sort |
forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters |
publisher |
De Gruyter |
series |
Open Life Sciences |
issn |
2391-5412 |
publishDate |
2016-01-01 |
description |
Objectives: As the member of the Fox family of transcription factors, Forkhead box M1 (FoxM1) is known to be critical in pathogenesis and development of many solid tumors. However, the clinical value and expression pattern in non-small cell lung cancer (NSCLC) is still poorly understood. Methods: In this study, real-time PCR was mainly applied to examine the gene expression levels of FoxM1 in 120 pairs of clinical NSCLC tissues, which were classified into different groups according to smoking status, lymph node metastasis, and tumor grade. By utilizing the online Kaplan-Meier plotter, overall survival analysis was performed to study the correlation between FoxM1 expression and prognosis of lung cancer (LC) patients. Afterwards, the correlation of FoxM1 gene expression and the clinical pathological parameters was examined by κ2 test in these 120 NSCLC patients. Results: FoxM1 was found to be aberrantly upregulated in NSCLC patients, and its overexpression was correlated to groups designated as smokers, cases of positive lymph node metastasis and cases of advanced tumor grades. Online survival analysis showed that high expression of FoxM1 predicted shorter overall survival of NSCLC patients. Additionally, FoxM1 upregulation was statistically correlated with positive smoking history, lymph node metastasis and higher tumor grades. Conclusion: FoxM1 is overexpressed in cancerous tissues and is associated with the poor prognosis of NSCLC patients. Our results provide insights into the utility of FoxM1 as an important biomarker and prognostic factor for NSCLC. |
topic |
foxm1 upregulation nsclc prognosis |
url |
https://doi.org/10.1515/biol-2016-0030 |
work_keys_str_mv |
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