Antihypertensive effects of astaxanthin
Hidekatsu Yanai1,2, Kumie Ito1,2, Hiroshi Yoshida2,3, Norio Tada1,21Department of Internal Medicine; 2Institute of Clinical Medicine and Research; 3Department of Laboratory Medicine, The Jikei University School of Medicine, Chiba, JapanAbstract: Astaxanthin is a biological antioxidant naturally foun...
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doaj-c5d632419e9a4179ba4f411dfd59b6e52020-11-25T00:55:18ZengDove Medical PressIntegrated Blood Pressure Control1178-71042008-10-012008default13Antihypertensive effects of astaxanthinHiroshi YoshidaKumie ItoHidekatsu YanaiNorio TadaHidekatsu Yanai1,2, Kumie Ito1,2, Hiroshi Yoshida2,3, Norio Tada1,21Department of Internal Medicine; 2Institute of Clinical Medicine and Research; 3Department of Laboratory Medicine, The Jikei University School of Medicine, Chiba, JapanAbstract: Astaxanthin is a biological antioxidant naturally found in a wide variety of aquatic living organisms, and has shown various pharmacological activities, such as anti-inflammatory and antidiabetic activities. A recent study reported that the administration of astaxanthin induced a significant reduction in blood pressure and delayed the incidence of stroke in stroke-prone spontaneously hypertensive rats, suggesting that astaxanthin also has antihypertensive effect. In a study using aortic rings of spontaneously hypertensive rats, astaxanthin induced a significant reduction of the contractile responses of the aorta to α-adrenergic receptor agonist and angiotensin II, which may contribute to the antihypertensive effect of astaxanthin. In a histopathological study, astaxanthin decreased coronary artery wall thickness compared with the control, indicating the possibility that astaxanthin ameliorates hypertension-induced vascular remodeling. Astaxanthin has anti-inflammatory, antidiabetic, antihypertensive, and antioxidative activities; therefore, we should perform further studies to elucidate an antiatherogenic effect of astaxanthin.Keywords: astaxanthin, antioxidant, antihypertensive effect, atherosclerosis http://www.dovepress.com/antihypertensive-effects-of-astaxanthin-a2507 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroshi Yoshida Kumie Ito Hidekatsu Yanai Norio Tada |
spellingShingle |
Hiroshi Yoshida Kumie Ito Hidekatsu Yanai Norio Tada Antihypertensive effects of astaxanthin Integrated Blood Pressure Control |
author_facet |
Hiroshi Yoshida Kumie Ito Hidekatsu Yanai Norio Tada |
author_sort |
Hiroshi Yoshida |
title |
Antihypertensive effects of astaxanthin |
title_short |
Antihypertensive effects of astaxanthin |
title_full |
Antihypertensive effects of astaxanthin |
title_fullStr |
Antihypertensive effects of astaxanthin |
title_full_unstemmed |
Antihypertensive effects of astaxanthin |
title_sort |
antihypertensive effects of astaxanthin |
publisher |
Dove Medical Press |
series |
Integrated Blood Pressure Control |
issn |
1178-7104 |
publishDate |
2008-10-01 |
description |
Hidekatsu Yanai1,2, Kumie Ito1,2, Hiroshi Yoshida2,3, Norio Tada1,21Department of Internal Medicine; 2Institute of Clinical Medicine and Research; 3Department of Laboratory Medicine, The Jikei University School of Medicine, Chiba, JapanAbstract: Astaxanthin is a biological antioxidant naturally found in a wide variety of aquatic living organisms, and has shown various pharmacological activities, such as anti-inflammatory and antidiabetic activities. A recent study reported that the administration of astaxanthin induced a significant reduction in blood pressure and delayed the incidence of stroke in stroke-prone spontaneously hypertensive rats, suggesting that astaxanthin also has antihypertensive effect. In a study using aortic rings of spontaneously hypertensive rats, astaxanthin induced a significant reduction of the contractile responses of the aorta to α-adrenergic receptor agonist and angiotensin II, which may contribute to the antihypertensive effect of astaxanthin. In a histopathological study, astaxanthin decreased coronary artery wall thickness compared with the control, indicating the possibility that astaxanthin ameliorates hypertension-induced vascular remodeling. Astaxanthin has anti-inflammatory, antidiabetic, antihypertensive, and antioxidative activities; therefore, we should perform further studies to elucidate an antiatherogenic effect of astaxanthin.Keywords: astaxanthin, antioxidant, antihypertensive effect, atherosclerosis |
url |
http://www.dovepress.com/antihypertensive-effects-of-astaxanthin-a2507 |
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