Interaction of gold nanoparticles with proteins and cells

Gold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application ra...

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Main Authors: Pengyang Wang, Xin Wang, Liming Wang, Xiaoyang Hou, Wei Liu, Chunying Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2015-06-01
Series:Science and Technology of Advanced Materials
Subjects:
Online Access:http://dx.doi.org/10.1088/1468-6996/16/3/034610
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spelling doaj-c5e8c183f50046bca90353649c6cba712020-11-25T02:53:43ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142015-06-0116310.1088/1468-6996/16/3/03461011661292Interaction of gold nanoparticles with proteins and cellsPengyang Wang0Xin Wang1Liming Wang2Xiaoyang Hou3Wei Liu4Chunying Chen5Guizhou Normal UniversityInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceGuizhou Normal UniversityInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceGold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application range may result in hazards to the environment and human health. Therefore, it is important to predict safety and evaluate therapeutic efficiency of Au NPs. It is necessary to establish proper approaches for the study of toxicity and biomedical effects. In this review, we first focus on the recent progress in biological effects of Au NPs at the molecular and cellular levels, and then introduce key techniques to study the interaction between Au NPs and proteins. Knowledge of the biomedical effects of Au NPs is significant for the rational design of functional nanomaterials and will help predict their safety and potential applications.http://dx.doi.org/10.1088/1468-6996/16/3/034610gold nanoparticlesprotein coronabiomedical effectcellular responsecytotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Pengyang Wang
Xin Wang
Liming Wang
Xiaoyang Hou
Wei Liu
Chunying Chen
spellingShingle Pengyang Wang
Xin Wang
Liming Wang
Xiaoyang Hou
Wei Liu
Chunying Chen
Interaction of gold nanoparticles with proteins and cells
Science and Technology of Advanced Materials
gold nanoparticles
protein corona
biomedical effect
cellular response
cytotoxicity
author_facet Pengyang Wang
Xin Wang
Liming Wang
Xiaoyang Hou
Wei Liu
Chunying Chen
author_sort Pengyang Wang
title Interaction of gold nanoparticles with proteins and cells
title_short Interaction of gold nanoparticles with proteins and cells
title_full Interaction of gold nanoparticles with proteins and cells
title_fullStr Interaction of gold nanoparticles with proteins and cells
title_full_unstemmed Interaction of gold nanoparticles with proteins and cells
title_sort interaction of gold nanoparticles with proteins and cells
publisher Taylor & Francis Group
series Science and Technology of Advanced Materials
issn 1468-6996
1878-5514
publishDate 2015-06-01
description Gold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application range may result in hazards to the environment and human health. Therefore, it is important to predict safety and evaluate therapeutic efficiency of Au NPs. It is necessary to establish proper approaches for the study of toxicity and biomedical effects. In this review, we first focus on the recent progress in biological effects of Au NPs at the molecular and cellular levels, and then introduce key techniques to study the interaction between Au NPs and proteins. Knowledge of the biomedical effects of Au NPs is significant for the rational design of functional nanomaterials and will help predict their safety and potential applications.
topic gold nanoparticles
protein corona
biomedical effect
cellular response
cytotoxicity
url http://dx.doi.org/10.1088/1468-6996/16/3/034610
work_keys_str_mv AT pengyangwang interactionofgoldnanoparticleswithproteinsandcells
AT xinwang interactionofgoldnanoparticleswithproteinsandcells
AT limingwang interactionofgoldnanoparticleswithproteinsandcells
AT xiaoyanghou interactionofgoldnanoparticleswithproteinsandcells
AT weiliu interactionofgoldnanoparticleswithproteinsandcells
AT chunyingchen interactionofgoldnanoparticleswithproteinsandcells
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