Interaction of gold nanoparticles with proteins and cells
Gold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application ra...
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2015-06-01
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Online Access: | http://dx.doi.org/10.1088/1468-6996/16/3/034610 |
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doaj-c5e8c183f50046bca90353649c6cba712020-11-25T02:53:43ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142015-06-0116310.1088/1468-6996/16/3/03461011661292Interaction of gold nanoparticles with proteins and cellsPengyang Wang0Xin Wang1Liming Wang2Xiaoyang Hou3Wei Liu4Chunying Chen5Guizhou Normal UniversityInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceGuizhou Normal UniversityInstitute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of ScienceGold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application range may result in hazards to the environment and human health. Therefore, it is important to predict safety and evaluate therapeutic efficiency of Au NPs. It is necessary to establish proper approaches for the study of toxicity and biomedical effects. In this review, we first focus on the recent progress in biological effects of Au NPs at the molecular and cellular levels, and then introduce key techniques to study the interaction between Au NPs and proteins. Knowledge of the biomedical effects of Au NPs is significant for the rational design of functional nanomaterials and will help predict their safety and potential applications.http://dx.doi.org/10.1088/1468-6996/16/3/034610gold nanoparticlesprotein coronabiomedical effectcellular responsecytotoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pengyang Wang Xin Wang Liming Wang Xiaoyang Hou Wei Liu Chunying Chen |
spellingShingle |
Pengyang Wang Xin Wang Liming Wang Xiaoyang Hou Wei Liu Chunying Chen Interaction of gold nanoparticles with proteins and cells Science and Technology of Advanced Materials gold nanoparticles protein corona biomedical effect cellular response cytotoxicity |
author_facet |
Pengyang Wang Xin Wang Liming Wang Xiaoyang Hou Wei Liu Chunying Chen |
author_sort |
Pengyang Wang |
title |
Interaction of gold nanoparticles with proteins and cells |
title_short |
Interaction of gold nanoparticles with proteins and cells |
title_full |
Interaction of gold nanoparticles with proteins and cells |
title_fullStr |
Interaction of gold nanoparticles with proteins and cells |
title_full_unstemmed |
Interaction of gold nanoparticles with proteins and cells |
title_sort |
interaction of gold nanoparticles with proteins and cells |
publisher |
Taylor & Francis Group |
series |
Science and Technology of Advanced Materials |
issn |
1468-6996 1878-5514 |
publishDate |
2015-06-01 |
description |
Gold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application range may result in hazards to the environment and human health. Therefore, it is important to predict safety and evaluate therapeutic efficiency of Au NPs. It is necessary to establish proper approaches for the study of toxicity and biomedical effects. In this review, we first focus on the recent progress in biological effects of Au NPs at the molecular and cellular levels, and then introduce key techniques to study the interaction between Au NPs and proteins. Knowledge of the biomedical effects of Au NPs is significant for the rational design of functional nanomaterials and will help predict their safety and potential applications. |
topic |
gold nanoparticles protein corona biomedical effect cellular response cytotoxicity |
url |
http://dx.doi.org/10.1088/1468-6996/16/3/034610 |
work_keys_str_mv |
AT pengyangwang interactionofgoldnanoparticleswithproteinsandcells AT xinwang interactionofgoldnanoparticleswithproteinsandcells AT limingwang interactionofgoldnanoparticleswithproteinsandcells AT xiaoyanghou interactionofgoldnanoparticleswithproteinsandcells AT weiliu interactionofgoldnanoparticleswithproteinsandcells AT chunyingchen interactionofgoldnanoparticleswithproteinsandcells |
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1724724891758886912 |