Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches

Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches

The brain tumor microenvironment has recently become a major challenge in all pediatric cancers, but especially in brain tumors like high-grade gliomas. Hypoxia is one of the extrinsic tumor features that interacts with tumor cells, but also with the blood–brain barrier and all normal brain cells. I...

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Bibliographic Details
Main Authors: Quentin Fuchs, Marina Pierrevelcin, Melissa Messe, Benoit Lhermitte, Anne-Florence Blandin, Christophe Papin, Andres Coca, Monique Dontenwill, Natacha Entz-Werlé
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
high-grade gliomas
pediatric
hypoxia
HIFs
Online Access:https://www.mdpi.com/2072-6694/12/4/979

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