Asymmetric Total Synthesis of Ieodomycin B

Asymmetric Total Synthesis of Ieodomycin B

Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 position...

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Bibliographic Details
Main Authors: Shuangjie Lin, Jianting Zhang, Zhibin Zhang, Tianxiang Xu, Shuangping Huang, Xiaoji Wang
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Marine Drugs
Subjects:
antimicrobial
total synthesis
ieodomycin B
chelation-controlled Mukaiyama aldol reaction
Online Access:http://www.mdpi.com/1660-3397/15/1/17

Internet

http://www.mdpi.com/1660-3397/15/1/17

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