is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months

Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11–60 years. 1 To our knowledge, no studies have examined the association of this polymorphism with wei...

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Main Authors:	Ann Chen Wu, Matthew W. Gillman, Elsie M. Taveras, Augusto A. Litonjua
Format:	Article
Language:	English
Published:	SAGE Publishing 2009-01-01
Series:	Clinical Medicine Insights: Pediatrics
Online Access:	https://doi.org/10.4137/CMPed.S2279

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spelling	doaj-c5f81a58d53349519fb066882abd59682020-11-25T03:26:31ZengSAGE PublishingClinical Medicine Insights: Pediatrics1179-55652009-01-01310.4137/CMPed.S2279 is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 MonthsAnn Chen Wu0Matthew W. Gillman1Elsie M. Taveras2Augusto A. Litonjua3Division of General Pediatrics, Children's Hospital, Boston, Massachusetts, U.S.A.Department of Nutrition, Harvard School of Public Health, Massachusetts, U.S.A.Division of General Pediatrics, Children's Hospital, Boston, Massachusetts, U.S.A.Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, U.S.A.Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11–60 years. 1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.https://doi.org/10.4137/CMPed.S2279
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ann Chen Wu Matthew W. Gillman Elsie M. Taveras Augusto A. Litonjua
spellingShingle	Ann Chen Wu Matthew W. Gillman Elsie M. Taveras Augusto A. Litonjua is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months Clinical Medicine Insights: Pediatrics
author_facet	Ann Chen Wu Matthew W. Gillman Elsie M. Taveras Augusto A. Litonjua
author_sort	Ann Chen Wu
title	is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months
title_short	is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months
title_full	is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months
title_fullStr	is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months
title_full_unstemmed	is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months
title_sort	is associated with lower gain in weight-for-length between birth and age 6 months
publisher	SAGE Publishing
series	Clinical Medicine Insights: Pediatrics
issn	1179-5565
publishDate	2009-01-01
description	Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11–60 years. 1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.
url	https://doi.org/10.4137/CMPed.S2279
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is Associated with Lower Gain in Weight-for-Length between Birth and Age 6 Months

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