African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker
Abstract Background Today, the development of new and well-tolerated anti-malarial drugs is strongly justified by the emergence of Plasmodium falciparum resistance. In 2014–2015, a phase 2b clinical study was conducted to evaluate the efficacy of a single oral dose of Artefenomel (OZ439)–piperaquine...
Main Authors: | Didier Leroy, Fiona Macintyre, Yeka Adoke, Serge Ouoba, Aissata Barry, Ghyslain Mombo-Ngoma, Jacques Mari Ndong Ngomo, Rosauro Varo, Yannelle Dossou, Antoinette Kitoto Tshefu, Tran Thanh Duong, Bui Quang Phuc, Bart Laurijssens, Roland Klopper, Nimol Khim, Eric Legrand, Didier Ménard |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-04-01
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Series: | Malaria Journal |
Online Access: | http://link.springer.com/article/10.1186/s12936-019-2756-4 |
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