Fetuin-A and type II diabetes mellitus
Background The pathophysiology of type II DM is complex; in addition to impaired insulin secretion from Beta-cells, reduced insulin sensitivity was found to play a predominant role in the pathogenesis of the disease. Fetuin-A is a he-patic secretory protein that binds the insulin receptor and inhib...
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doaj-c60bcb929fe4414f8b2e46b9ec4fe85d2020-11-25T03:57:40ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982014-01-0126415716110.4103/1110-7782.148140Fetuin-A and type II diabetes mellitusLamyaa Ismail AhmedSabila Gomaa MousaNagwa Abd El-Ghaffar MohamedZeinab Ahmed YousryMayada Rabea Abd-El KhalaaBackground The pathophysiology of type II DM is complex; in addition to impaired insulin secretion from Beta-cells, reduced insulin sensitivity was found to play a predominant role in the pathogenesis of the disease. Fetuin-A is a he-patic secretory protein that binds the insulin receptor and inhibits insulin action both in vivo and in vitro. Objective Our aim was to investigate whether serum fetuin-A levels predict the incidence of insulin resistance in type II DM. Patient and methods The present study included 40 patients who had type II diabetes mellitus served as patients group and 40 apparently normal individuals served as control group. All patient and control groups were subjected to the following: full medical history and thorough physical examination, fasting & post prandial blood glucose, urea, creatinine, lipid profile, CRP, insulin and fetuin-A. Results There was highly significant increase in serum insulin, serum fetuin A and HOMA-IR in diabetic group compared with control group. There was significant positive correlation between serum fetuin A and serum insulin, FBG, HbA1c and serum CRP. Also a significant positive correlation between HOMA-IR and serum fetuin A, serum insulin and HbA1c were found. Conclusion We concluded that fetuin-A may play a role in the pathogenesis of type II DM, and high serum fetuin-A has a strong association with IR and glycemic control in type II diabetic patients. Future studies are recommended to establish the possibility of using fetuin-A as a predictor of insulin resistance in type II diabetic patients.http://www.esim.eg.net/article.asp?issn=1110-7782;year=2014;volume=26;issue=4;spage=157;epage=161;aulast=AhmedC-reactive protein, diabetes mellitus, fetuin-A, insulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lamyaa Ismail Ahmed Sabila Gomaa Mousa Nagwa Abd El-Ghaffar Mohamed Zeinab Ahmed Yousry Mayada Rabea Abd-El Khalaa |
spellingShingle |
Lamyaa Ismail Ahmed Sabila Gomaa Mousa Nagwa Abd El-Ghaffar Mohamed Zeinab Ahmed Yousry Mayada Rabea Abd-El Khalaa Fetuin-A and type II diabetes mellitus The Egyptian Journal of Internal Medicine C-reactive protein, diabetes mellitus, fetuin-A, insulin resistance |
author_facet |
Lamyaa Ismail Ahmed Sabila Gomaa Mousa Nagwa Abd El-Ghaffar Mohamed Zeinab Ahmed Yousry Mayada Rabea Abd-El Khalaa |
author_sort |
Lamyaa Ismail Ahmed |
title |
Fetuin-A and type II diabetes mellitus |
title_short |
Fetuin-A and type II diabetes mellitus |
title_full |
Fetuin-A and type II diabetes mellitus |
title_fullStr |
Fetuin-A and type II diabetes mellitus |
title_full_unstemmed |
Fetuin-A and type II diabetes mellitus |
title_sort |
fetuin-a and type ii diabetes mellitus |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Internal Medicine |
issn |
1110-7782 2090-9098 |
publishDate |
2014-01-01 |
description |
Background
The pathophysiology of type II DM is complex; in addition to impaired insulin secretion from Beta-cells, reduced insulin sensitivity was found to play a predominant role in the pathogenesis of the disease. Fetuin-A is a he-patic secretory protein that binds the insulin receptor and inhibits insulin action both in vivo and in vitro.
Objective
Our aim was to investigate whether serum fetuin-A levels predict the incidence of insulin resistance in type II DM.
Patient and methods
The present study included 40 patients who had type II diabetes mellitus served as patients group and 40 apparently normal individuals served as control group. All patient and control groups were subjected to the following: full medical history and thorough physical examination, fasting & post prandial blood glucose, urea, creatinine, lipid profile, CRP, insulin and fetuin-A.
Results
There was highly significant increase in serum insulin, serum fetuin A and HOMA-IR in diabetic group compared with control group. There was significant positive correlation between serum fetuin A and serum insulin, FBG, HbA1c and serum CRP. Also a significant positive correlation between HOMA-IR and serum fetuin A, serum insulin and HbA1c were found.
Conclusion
We concluded that fetuin-A may play a role in the pathogenesis of type II DM, and high serum fetuin-A has a strong association with IR and glycemic control in type II diabetic patients. Future studies are recommended to establish the possibility of using fetuin-A as a predictor of insulin resistance in type II diabetic patients. |
topic |
C-reactive protein, diabetes mellitus, fetuin-A, insulin resistance |
url |
http://www.esim.eg.net/article.asp?issn=1110-7782;year=2014;volume=26;issue=4;spage=157;epage=161;aulast=Ahmed |
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