Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization...
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/6/856 |
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doaj-c613f92b989c4f279d2cacd576d437482021-06-30T23:09:06ZengMDPI AGGenes2073-44252021-06-011285685610.3390/genes12060856Subcellular Localization of miRNAs and Implications in Cellular HomeostasisMinwen Jie0Tong Feng1Wei Huang2Moran Zhang3Yuliang Feng4Hao Jiang5Zhili Wen6Laboratory for Aging and Cancer Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, ChinaLaboratory for Aging and Cancer Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADepartment of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, Headington, Oxford OX3 7LD, UKLaboratory for Aging and Cancer Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaMicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization of miRNAs. Based on miRNA subcellular localization, unconventional functions and mechanisms at the transcriptional and post-transcriptional levels have been identified. This minireview provides an overview of the subcellular localization of miRNAs and the mechanisms by which they regulate transcription and cellular homeostasis in mammals, with a particular focus on the roles of phase-separated biomolecular condensates.https://www.mdpi.com/2073-4425/12/6/856microRNAsubcellular localizationtranscriptional regulationphase separationcondensate |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Minwen Jie Tong Feng Wei Huang Moran Zhang Yuliang Feng Hao Jiang Zhili Wen |
| spellingShingle |
Minwen Jie Tong Feng Wei Huang Moran Zhang Yuliang Feng Hao Jiang Zhili Wen Subcellular Localization of miRNAs and Implications in Cellular Homeostasis Genes microRNA subcellular localization transcriptional regulation phase separation condensate |
| author_facet |
Minwen Jie Tong Feng Wei Huang Moran Zhang Yuliang Feng Hao Jiang Zhili Wen |
| author_sort |
Minwen Jie |
| title |
Subcellular Localization of miRNAs and Implications in Cellular Homeostasis |
| title_short |
Subcellular Localization of miRNAs and Implications in Cellular Homeostasis |
| title_full |
Subcellular Localization of miRNAs and Implications in Cellular Homeostasis |
| title_fullStr |
Subcellular Localization of miRNAs and Implications in Cellular Homeostasis |
| title_full_unstemmed |
Subcellular Localization of miRNAs and Implications in Cellular Homeostasis |
| title_sort |
subcellular localization of mirnas and implications in cellular homeostasis |
| publisher |
MDPI AG |
| series |
Genes |
| issn |
2073-4425 |
| publishDate |
2021-06-01 |
| description |
MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization of miRNAs. Based on miRNA subcellular localization, unconventional functions and mechanisms at the transcriptional and post-transcriptional levels have been identified. This minireview provides an overview of the subcellular localization of miRNAs and the mechanisms by which they regulate transcription and cellular homeostasis in mammals, with a particular focus on the roles of phase-separated biomolecular condensates. |
| topic |
microRNA subcellular localization transcriptional regulation phase separation condensate |
| url |
https://www.mdpi.com/2073-4425/12/6/856 |
| work_keys_str_mv |
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| _version_ |
1721352046771175424 |