Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair
In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating di...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/14/1/1031 |
id |
doaj-c61d742cd62c47759726cd7e7aa5a26e |
---|---|
record_format |
Article |
spelling |
doaj-c61d742cd62c47759726cd7e7aa5a26e2020-11-24T21:43:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-01-011411031104910.3390/ijms14011031Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin RepairJennifer K. SaboHolly S. CateIn demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating disorders. Endogenous precursor cells or exogenous transplanted cells are potential sources for remyelinating oligodendrocytes in the central nervous system (CNS). Several signalling pathways have been implicated in regulating the capacity of these cell populations for myelin repair. Here, we review neural precursor cells and oligodendrocyte progenitor cells as potential sources for remyelinating oligodendrocytes and evidence for the functional role of key signalling pathways in inhibiting regeneration from these precursor cell populations.http://www.mdpi.com/1422-0067/14/1/1031oligodendrocyte progenitor cell (OPC)neural precursor cell (NPC)bone morphogenic protein (BMP)central nervous system (CNS) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jennifer K. Sabo Holly S. Cate |
spellingShingle |
Jennifer K. Sabo Holly S. Cate Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair International Journal of Molecular Sciences oligodendrocyte progenitor cell (OPC) neural precursor cell (NPC) bone morphogenic protein (BMP) central nervous system (CNS) |
author_facet |
Jennifer K. Sabo Holly S. Cate |
author_sort |
Jennifer K. Sabo |
title |
Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair |
title_short |
Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair |
title_full |
Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair |
title_fullStr |
Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair |
title_full_unstemmed |
Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair |
title_sort |
signalling pathways that inhibit the capacity of precursor cells for myelin repair |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2013-01-01 |
description |
In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating disorders. Endogenous precursor cells or exogenous transplanted cells are potential sources for remyelinating oligodendrocytes in the central nervous system (CNS). Several signalling pathways have been implicated in regulating the capacity of these cell populations for myelin repair. Here, we review neural precursor cells and oligodendrocyte progenitor cells as potential sources for remyelinating oligodendrocytes and evidence for the functional role of key signalling pathways in inhibiting regeneration from these precursor cell populations. |
topic |
oligodendrocyte progenitor cell (OPC) neural precursor cell (NPC) bone morphogenic protein (BMP) central nervous system (CNS) |
url |
http://www.mdpi.com/1422-0067/14/1/1031 |
work_keys_str_mv |
AT jenniferksabo signallingpathwaysthatinhibitthecapacityofprecursorcellsformyelinrepair AT hollyscate signallingpathwaysthatinhibitthecapacityofprecursorcellsformyelinrepair |
_version_ |
1725914219987075072 |