Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones

Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones

Designing a suitable scaffold matching the mechanical properties of natural bones to optimize the bone regeneration is required in bone tissue engineering. The present work developed a single-parameter design method for the octet truss topological scaffold to achieve the accurate prediction and flex...

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Main Authors: Luping Wang, Qiang Chen, Prasad K.D.V. Yarlagadda, Feipeng Zhu, Qiwei Li, Zhiyong Li
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Materials & Design
Subjects:
3D-printing
Young’s modulus
Strength
Cellular solid
Structure design
Mathematical model
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127521005402
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spelling doaj-c64c1e3b85b4403fb047e1591e2271ba2021-09-27T04:23:48ZengElsevierMaterials & Design0264-12752021-11-01209109986Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bonesLuping Wang0Qiang Chen1Prasad K.D.V. Yarlagadda2Feipeng Zhu3Qiwei Li4Zhiyong Li5Biomechanics Laboratory, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane QLD 4000, AustraliaBiomechanics Laboratory, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane QLD 4000, AustraliaCollege of Mechanics and Materials, Hohai University, Nanjing 211100, ChinaBio-inspired Materials and Devices Laboratory, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaBiomechanics Laboratory, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane QLD 4000, Australia; Corresponding author at: Biomechanics Laboratory, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.Designing a suitable scaffold matching the mechanical properties of natural bones to optimize the bone regeneration is required in bone tissue engineering. The present work developed a single-parameter design method for the octet truss topological scaffold to achieve the accurate prediction and flexible adjustment of its Young’s modulus and strength. A theoretical model that formulated the normalized Young’s modulus and normalized yield strength of the octet truss scaffold by the single parameter (d/Ø) was proposed and further validated by uniaxial compression tests and FEA simulations. On the basis of the proposed model, the Young's modulus and yield strength of the octet truss scaffold made of different polymers with different d/Ø were mapped, and the ranges of suitable d/Ø that match the different natural cancellous bones were suggested. The results showed that the design method could accurately predict the porosity, specific area, normalized Young’s modulus and normalized yield strength, and adjust the mechanical properties of the scaffold in a wide range. The present work can be used for the design of scaffolds and the selection of constituent materials to obtain a suitable scaffold with desired mechanical properties, and has application prospects in the fields of bone tissue engineering and regenerative medicine.http://www.sciencedirect.com/science/article/pii/S02641275210054023D-printingYoung’s modulusStrengthCellular solidStructure designMathematical model
collection DOAJ
language English
format Article
sources DOAJ
author Luping Wang
Qiang Chen
Prasad K.D.V. Yarlagadda
Feipeng Zhu
Qiwei Li
Zhiyong Li
spellingShingle Luping Wang
Qiang Chen
Prasad K.D.V. Yarlagadda
Feipeng Zhu
Qiwei Li
Zhiyong Li
Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones
Materials & Design
3D-printing
Young’s modulus
Strength
Cellular solid
Structure design
Mathematical model
author_facet Luping Wang
Qiang Chen
Prasad K.D.V. Yarlagadda
Feipeng Zhu
Qiwei Li
Zhiyong Li
author_sort Luping Wang
title Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones
title_short Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones
title_full Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones
title_fullStr Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones
title_full_unstemmed Single-parameter mechanical design of a 3D-printed octet truss topological scaffold to match natural cancellous bones
title_sort single-parameter mechanical design of a 3d-printed octet truss topological scaffold to match natural cancellous bones
publisher Elsevier
series Materials & Design
issn 0264-1275
publishDate 2021-11-01
description Designing a suitable scaffold matching the mechanical properties of natural bones to optimize the bone regeneration is required in bone tissue engineering. The present work developed a single-parameter design method for the octet truss topological scaffold to achieve the accurate prediction and flexible adjustment of its Young’s modulus and strength. A theoretical model that formulated the normalized Young’s modulus and normalized yield strength of the octet truss scaffold by the single parameter (d/Ø) was proposed and further validated by uniaxial compression tests and FEA simulations. On the basis of the proposed model, the Young's modulus and yield strength of the octet truss scaffold made of different polymers with different d/Ø were mapped, and the ranges of suitable d/Ø that match the different natural cancellous bones were suggested. The results showed that the design method could accurately predict the porosity, specific area, normalized Young’s modulus and normalized yield strength, and adjust the mechanical properties of the scaffold in a wide range. The present work can be used for the design of scaffolds and the selection of constituent materials to obtain a suitable scaffold with desired mechanical properties, and has application prospects in the fields of bone tissue engineering and regenerative medicine.
topic 3D-printing
Young’s modulus
Strength
Cellular solid
Structure design
Mathematical model
url http://www.sciencedirect.com/science/article/pii/S0264127521005402
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AT qiangchen singleparametermechanicaldesignofa3dprintedoctettrusstopologicalscaffoldtomatchnaturalcancellousbones
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AT qiweili singleparametermechanicaldesignofa3dprintedoctettrusstopologicalscaffoldtomatchnaturalcancellousbones
AT zhiyongli singleparametermechanicaldesignofa3dprintedoctettrusstopologicalscaffoldtomatchnaturalcancellousbones
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