Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance

<i>Background:</i> tyrosine kinase inhibitors (TKIs) inhibit phosphorylation of signaling proteins. TKIs often show large variations in the clinic due to poor pharmacology, possibly leading to resistance. We compared gut absorption of inhibitors of epidermal growth factor receptor (erlot...

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Bibliographic Details
Main Authors: Richard J. Honeywell, Ietje Kathmann, Elisa Giovannetti, Carmelo Tibaldi, Egbert F. Smit, Maria N. Rovithi, Henk M.W. Verheul, Godefridus J. Peters
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
tyrosine kinase inhibitors
CaCo2 model system
gut-epithelial transfer
efflux ratio
red blood cell accumulation
Online Access:https://www.mdpi.com/2072-6694/12/11/3322

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