Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives
Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially d...
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doaj-c64ee2559347467ab81557b31b27c1142020-12-22T00:02:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-01219760976010.3390/ijms21249760Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future PerspectivesLei Wang0Chaojun Tang1Cyrus Tang Hematology Center, Cyrus Tang Medical Institute, Soochow University, Suzhou 215123, ChinaCyrus Tang Hematology Center, Cyrus Tang Medical Institute, Soochow University, Suzhou 215123, ChinaBesides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites under disturbed blood flow with low speeds and chaotic directions. Hyperglycemia, hyperlipidemia, and hypertension are all risk factors for atherosclerosis. When the vascular microenvironment changes, platelets can respond quickly to interact with endothelial cells and leukocytes, participating in atherosclerosis. This review discusses the important roles of platelets in the plaque formation under pro-atherogenic factors. Specifically, we discussed the platelet behaviors under disturbed flow, hyperglycemia, and hyperlipidemia conditions. We also summarized the molecular mechanisms involved in vascular inflammation during atherogenesis based on platelet receptors and secretion of inflammatory factors. Finally, we highlighted the studies of platelet migration in atherogenesis. In general, we elaborated an atherogenic role of platelets and the aspects that should be further studied in the future.https://www.mdpi.com/1422-0067/21/24/9760plateletatherogenesisdisturbed flowhyperglycemiahyperlipidemiainflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Wang Chaojun Tang |
spellingShingle |
Lei Wang Chaojun Tang Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives International Journal of Molecular Sciences platelet atherogenesis disturbed flow hyperglycemia hyperlipidemia inflammation |
author_facet |
Lei Wang Chaojun Tang |
author_sort |
Lei Wang |
title |
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives |
title_short |
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives |
title_full |
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives |
title_fullStr |
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives |
title_full_unstemmed |
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives |
title_sort |
targeting platelet in atherosclerosis plaque formation: current knowledge and future perspectives |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-12-01 |
description |
Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites under disturbed blood flow with low speeds and chaotic directions. Hyperglycemia, hyperlipidemia, and hypertension are all risk factors for atherosclerosis. When the vascular microenvironment changes, platelets can respond quickly to interact with endothelial cells and leukocytes, participating in atherosclerosis. This review discusses the important roles of platelets in the plaque formation under pro-atherogenic factors. Specifically, we discussed the platelet behaviors under disturbed flow, hyperglycemia, and hyperlipidemia conditions. We also summarized the molecular mechanisms involved in vascular inflammation during atherogenesis based on platelet receptors and secretion of inflammatory factors. Finally, we highlighted the studies of platelet migration in atherogenesis. In general, we elaborated an atherogenic role of platelets and the aspects that should be further studied in the future. |
topic |
platelet atherogenesis disturbed flow hyperglycemia hyperlipidemia inflammation |
url |
https://www.mdpi.com/1422-0067/21/24/9760 |
work_keys_str_mv |
AT leiwang targetingplateletinatherosclerosisplaqueformationcurrentknowledgeandfutureperspectives AT chaojuntang targetingplateletinatherosclerosisplaqueformationcurrentknowledgeandfutureperspectives |
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1724374620119760896 |